A connectome-based approach to assess motor outcome after neonatal arterial ischemic stroke

被引:7
作者
Al Harrach, Mariam [1 ,2 ]
Pretzel, Pablo [3 ]
Groeschel, Samuel [3 ]
Rousseau, Francois [4 ]
Dhollander, Thijs [5 ]
Hertz-Pannier, Lucie [6 ]
Lefevre, Julien [7 ]
Chabrier, Stephane [8 ,9 ]
Dinomais, Mickael [1 ,10 ,11 ]
机构
[1] Univ Angers, Lab Angevin Rech Ingn Syst LARIS EA7312, F-49000 Angers, France
[2] Univ Rennes 1, Lab Traitement Signal & Image LTSI, INSERM U1099, F-35000 Rennes, France
[3] Univ Hosp Tubingen, Dept Child Neurol, Expt Paediat Neuroimaging, Tubingen, Germany
[4] UBL, IMT Atlantique, INSERM U1101 LaTIM, F-29200 Brest, France
[5] Murdoch Childrens Res Inst, Dev Imaging, Melbourne, Vic, Australia
[6] Univ Paris, UNIACT, Neurospin, Inst Joliot,CEA Paris Saclay,Inserm U114, F-91191 Gif Sur Yvette, France
[7] Aix Marseille Univ, Inst Neurosci Timone, UMR 7289, CNRS, F-13385 Marseille, France
[8] Univ Lyon, Univ St Etienne, INSERM, UMR1059 Sainbiose, F-42023 St Etienne, France
[9] CHU St Etienne, Paediat Phys & Rehabil Med Dept, French Ctr Paediat Stroke, INSERM,CIC 1408, F-42055 St Etienne, France
[10] CHU Angers, Dept Med Phys & Readapt, Angers, France
[11] CHU Angers, LUNAM, Angers, France
关键词
STRUCTURAL CONNECTIVITY; PERINATAL STROKE; HAND FUNCTION; DIFFUSION MRI; REORGANIZATION; INHIBITION; NETWORKS; CHILDREN; RECOVERY; PREDICT;
D O I
10.1002/acn3.51292
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Objective: Studies of motor outcome after Neonatal Arterial Ischemic Stroke (NAIS) often rely on lesion mapping using MRI. However, clinical measurements indicate that motor deficit can be different than what would solely be anticipated by the lesion extent and location. Because this may be explained by the cortical disconnections between motor areas due to necrosis following the stroke, the investigation of the motor network can help in the understanding of visual inspection and outcome discrepancy. In this study, we propose to examine the structural connectivity between motor areas in NAIS patients compared to healthy controls in order to define the cortical and subcortical connections that can reflect the motor outcome. Methods: Thirty healthy controls and 32 NAIS patients with and without Cerebral Palsy (CP) underwent MRI acquisition and manual assessment. The connectome of all participants was obtained from T1-weighted and diffusion-weighted imaging. Results: Significant disconnections in the lesioned and contra-lesioned hemispheres of patients were found. Furthermore, significant correlations were detected between the structural connectivity metric of specific motor areas and manuality assessed by the Box and Block Test (BBT) scores in patients. Interpretation: Using the connectivity measures of these links, the BBT score can be estimated using a multiple linear regression model. In addition, the presence or not of CP can also be predicted using the KNN classification algorithm. According to our results, the structural connectome can be an asset in the estimation of gross manual dexterity and can help uncover structural changes between brain regions related to NAIS.
引用
收藏
页码:1024 / 1037
页数:14
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