Base Promoted Three-Component Annulation of 4-Diazoisochroman-3-imines with Dimethylsulfonium Ylides: Synthesis of Highly Functionalized Isochromeno[4,3-c]pyridazines

被引：11

作者：

Suleman, Muhammad ^{[1
]}

Xie, Jianwei ^{[1
]}

Wang, Zaibin ^{[1
]}

Lu, Ping ^{[1
]}

Wang, Yanguang ^{[1
]}

机构：

[1] Zhejiang Univ, Dept Chem, Hangzhou 310027, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2021年 / 86卷 / 01期

基金：

中国国家自然科学基金;

关键词：

PYRIDAZINE RING CARBONS; NUCLEOPHILIC-SUBSTITUTION; DIAZO-COMPOUNDS; DERIVATIVES; COMPLEXES; 3-DIAZOINDOLIN-2-IMINES; CHEMISTRY; ALDEHYDES; DIAZINES; ESTERS;

D O I：

10.1021/acs.joc.0c02204

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel method has been developed to synthesize a unique class of highly functionalized isochromeno[4,3c]-pyridazines. This reaction features an intermolecular functionalization of terminal nitrogen atom of diazo group of 4-diazoisochoman-3-imine with two dimethylsulfonium ylide components, followed by a base promoted 6-exo-trig cyclization step. Readily available starting materials, a broad substrate scope, and operationally simple, mild, and catalyst-free reaction conditions are the prominent features of this method.

引用

页码：455 / 465

页数：11

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