Synthesis and vasodilatory activity of some amide derivatives of 6-(4-carboxymethyloxyphenyl)-4,5-dihydro-3(2H)-pyridazinone

被引：38

作者：

Bansal, Ranju ^{[1
]}

Kumar, Dinesh ^{[1
]}

Carron, Rosalia ^{[2
]}

de la Calle, Carmen ^{[2
]}

机构：

[1] Panjab Univ, Univ Inst Pharmaceut Sci, Sector 14, Chandigarh 160014, India

[2] Univ Salamanca, Fac Farm, Dept Fisiol & Farmacol, E-37007 Salamanca, Spain

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2009年 / 44卷 / 11期

关键词：

Hypertension; Pyridazinones; Hydrazine derivatives; Vasodilatory activity; PYRIDAZINONE;

D O I：

10.1016/j.ejmech.2009.06.006

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Synthesis and vasodilatory activity of some amide derivatives of 6-(4-carboxymethyloxyphenyl)-4,5-dihydro-3(2H)-pyridazinone are reported. An effect of substitution at 2-position of pyridazinone ring on vasodilatory potential has also been explored. The most active compound 6-[4-(2-oxo-2-pyrrolidin-1-yl-ethoxy)phenyl]-2-(4-fluorophenyl)-4,5-dihydropyridazin-3(2H)-one (11) exhibited vasodilating activity in nanomolar range (IC(50) = 0.051 mu M). (C) 2009 Elsevier Masson SAS. All rights reserved.

引用

页码：4441 / 4447

页数：7

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