Hyperhomocysteinemia and Cardiovascular Disease: Is the Adenosinergic System the Missing Link?

被引：56
作者：
Paganelli, Franck [1 ,2 ]
Mottola, Giovanna [1 ,3 ]
Fromonot, Julien [1 ,3 ]
Marlinge, Marion [1 ,3 ]
Deharo, Pierre [1 ,4 ]
Guieu, Regis [1 ,3 ]
Ruf, Jean [1 ]
机构：
[1] Aix Marseille Univ, C2VN, INSERM, INRAE, F-13005 Marseille, France
[2] North Hosp, Dept Cardiol, F-13015 Marseille, France
[3] Timone Hosp, Biochem Lab, F-13005 Marseille, France
[4] Timone Hosp, Dept Cardiol, F-13005 Marseille, France
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 04期
关键词：
adenosine; adenosine A(2A) receptors; cardiovascular disease; hydrogen sulfide; hyperhomocysteinemia; PLASMA HOMOCYSTEINE LEVELS; CORONARY-ARTERY-DISEASE; ENDOGENOUS HYDROGEN-SULFIDE; GASEOUS SIGNALING MOLECULE; AORTIC ENDOTHELIAL-CELLS; SMOOTH-MUSCLE-CELLS; A(2A) RECEPTORS; BLOOD-PRESSURE; ECTO-5'-NUCLEOTIDASE CD73; PATHWAY CONTRIBUTES;
D O I：
10.3390/ijms22041690
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The influence of hyperhomocysteinemia (HHCy) on cardiovascular disease (CVD) remains unclear. HHCy is associated with inflammation and atherosclerosis, and it is an independent risk factor for CVD, stroke and myocardial infarction. However, homocysteine (HCy)-lowering therapy does not affect the inflammatory state of CVD patients, and it has little influence on cardiovascular risk. The HCy degradation product hydrogen sulfide (H2S) is a cardioprotector. Previous research proposed a positive role of H2S in the cardiovascular system, and we discuss some recent data suggesting that HHCy worsens CVD by increasing the production of H2S, which decreases the expression of adenosine A(2A) receptors on the surface of immune and cardiovascular cells to cause inflammation and ischemia, respectively.
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页码：1 / 20
页数：20
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