Late-Stage Functionalization of Aromatic Acids with Aliphatic Aziridines: Direct Approach to Form β-Branched Arylethylamine Backbones

被引:40
作者
Zhou, Kehan [1 ]
Zhu, Yan [1 ]
Fan, Weitai [1 ]
Chen, Yujie [1 ]
Xu, Xu [1 ]
Zhang, Jingyu [1 ]
Zhao, Yingsheng [1 ]
机构
[1] Soochow Univ, Coll Chem Chem Engn & Mat Sci, Key Lab Organ Synth Jiangsu Prov, Suzhou 215123, Peoples R China
关键词
aziridines; aromatic acid; C-H activation; C-C bond formation; palladium catalyst; C-H ALKYLATION; ARENES; ARYLATION; EPOXIDES; LIGANDS; META;
D O I
10.1021/acscatal.9b01347
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
A palladium-catalyzed carboxylic acid-directed cross-coupling of an ortho-C(sp(2)) atom of aromatic acids with aliphatic aziridines to construct the beta-arylethylamine skeleton via C-H activation has been developed. The reaction proceeded under mild conditions with great substrate scope. Meanwhile, the beta-arylethylamine skeleton in drugs or bioactive compounds could be easily generated in a single step. A catalytic amount of cesium carbonate was crucial to realizing the selective beta-arylethylamine synthesis.
引用
收藏
页码:6738 / 6743
页数:11
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