Maternal exposure of triclosan cause intrauterine development restriction, delay in puberty installation and deregulation of testicular function in rat offspring

被引：2

作者：

Machado, Camila Stacheski ^{[1
]}

de Arruda Amorim, Joao Paulo ^{[1
]}

Welter, Romario Willian ^{[1
]}

Machado, Michael Aparecido ^{[1
]}

Porto Amorim, Elaine Manoela ^{[1
]}

机构：

[1] Univ Estadual Oeste Parana, Rua Univ 1619, BR-85819110 Cascavel, Parana, Brazil

来源：

ACTA SCIENTIARUM-HEALTH SCIENCES | 2019年 / 41卷

关键词：

triclosan; endocrine desregulation; puberty; spermatogenesis; rat; ENDOCRINE DISRUPTING CHEMICALS; MOLECULAR-MECHANISMS; HORMONE RECEPTORS; FETAL; EXPRESSION; DECREASES; THYROXINE; GROWTH; STEROIDOGENESIS; TESTOSTERONE;

D O I：

10.4025/actascihealthsci.v41i1.37929

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

This study aimed to evaluate the effects of maternal exposure to triclosan (TCS), during gestation and lactation on physical development, puberty installation and testicular function of male offspring in puberty and sexual maturity. Sixteen pregnant Wistar rats were used and divided into four experimental groups: GI- they received corn oil daily by gavage; GII- they received 75 mg kg(-1) day(-1) of TCS; GIII- they received 150 mg kg(-1) day(-1) of TCS and GIV- they received 300 mg kg(-1) day(-1) of TCS during pregnancy and lactation. The mean weight of the treated rat's offspring was lower in comparison to GI group. In the exposed offspring. A delay in puberty installation was observed following the exposure to triclosan. Regarding to the stages of the seminiferous epithelium in puberty, it was noticed an increase of the I-VI stages in GIV group, compared with to GI. In sexual maturity, it was observed an increase of VII-VIII, IX-XIII in contrast to a reduction of XIV stage in treated animals, comparing to GI. There was no difference in the number of Sertoli cells. We conclude that the maternal exposure to TCS during gestation and lactation causes restriction of the intrauterine development, delay in the puberty installation and deregulation in the seminiferous epithelium cycle.

引用

页数：12

共 4 条

[1] Maternal exposure to triclosan causes fetal development restriction, deregulation of the oestrous cycle, and alters uterine tissue in rat offspring
Bitencourt, Guilherme
Fortunato, Eduardo D.
Panis, Carolina
Amorim, Elaine M. P.
de Arruda Amorim, Joao P.
ENVIRONMENTAL TOXICOLOGY, 2019, 34 (10) : 1105 - 1113
[2] Maternal CBZ exposure impairs testicular development, spermatogenesis and sperm parameters in male offspring at puberty
de Oliva, Samara Urban
Engelbrecht, Rafael de Mendonca
Miraglia, Sandra Maria
ANDROLOGIA, 2020, 52 (09)
[3] Delay and Impairment in Brain Development and Function in Rat Offspring After Maternal Exposure to Methylmercury
Radonjic, Marijana
Cappaert, Natalie L. M.
de Vries, Erik F. J.
de Esch, Celine E. F.
Kuper, Frieke C.
van Waarde, Aren
Dierckx, Rudi A. J. O.
Wadman, Wytse J.
Wolterbeek, Andre P. M.
Stierum, Rob H.
de Groot, Didima M. G.
TOXICOLOGICAL SCIENCES, 2013, 133 (01) : 112 - 124
[4] Maternal dietary chromium restriction programs muscle development and function in the rat offspring
Padmavathi, Inagadapa J. N.
Rao, Kalashikam Rajender
Venu, Lagishetty
Ismail, Ayesha
Raghunath, Manchala
EXPERIMENTAL BIOLOGY AND MEDICINE, 2010, 235 (03) : 349 - 355

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