Gold nanoparticles for enhanced single molecule fluorescence analysis at micromolar concentration

被引：37
|
作者：
Punj, Deep [1 ]
de Torres, Juan [1 ]
Rigneault, Herve [1 ]
Wenger, Jerome [1 ]
机构：
[1] Aix Marseille Univ, CNRS, Cent Marseille, Inst Fresnel, F-13013 Marseille, France
来源：
OPTICS EXPRESS | 2013年 / 21卷 / 22期
关键词：
CORRELATION SPECTROSCOPY; PLASMONIC ANTENNA; NANOANTENNAS; APERTURES; FIELD;
D O I：
10.1364/OE.21.027338
中图分类号：
O43 [光学];
学科分类号：
070207 ; 0803 ;
摘要：
Individual metal nanoparticles represent an inexpensive and versatile platform to enhance the detection of fluorescent species at biologically relevant concentrations. Here we use fluorescence correlation spectroscopy to quantify the near-field detection volume and average fluorescence enhancement factors set by a single gold nanoparticle. We demonstrate detection volumes down to 270 zeptoliters (three orders of magnitude beyond the diffraction barrier) together with 60-fold enhancement of the fluorescence brightness per molecule. (C) 2013 Optical Society of America
引用
收藏
页码：27338 / 27343
页数：6
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