Site-Selective Azaindole Arylation at the Azine and Azole Rings via N-Oxide Activation

被引：130

作者：

Huestis, Malcolm P. ^{[1
]}

Fagnou, Keith ^{[1
]}

机构：

[1] Univ Ottawa, Ctr Catalysis Res & Innovat, Dept Chem, Ottawa, ON K1N 6J7, Canada

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 06期

基金：

加拿大自然科学与工程研究理事会;

关键词：

C-H BOND; CATALYZED DIRECT ARYLATION; DIRECT C-2 ARYLATION; CROSS-COUPLING REACTIONS; ROOM-TEMPERATURE; ARYL CHLORIDES; ARENES; FUNCTIONALIZATION; ALKENYLATION; HETEROCYCLES;

D O I：

10.1021/ol900150u

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Subjection of N-methyl 6- and 7-azaindole N-oxides to a Pd(OAc)(2)/DavePhos catalyst system enables regioselective direct arylation of the azine ring. Following deoxygenation, 7-azaindole substrates undergo an additional regioselective azole direct arylation event in good yield.

引用

页码：1357 / 1360

页数：4

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