The distinctive role of small heat shock proteins in oncogenesis

被引：9
作者：
Laudanski, K
Wyczechowska, D
机构：
[1] Griffin Hosp, Dept Med, Derby, CT 06418 USA
[2] Med Univ Lodz, Dept Med Chem, Lodz, Poland
来源：
ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS | 2006年 / 54卷 / 02期
关键词：
small heat shock proteins; alpha A-crystallin; alpha B-crystallin; HSP-27; carcinogenesis; neoplasm; immune system;
D O I：
10.1007/s00005-006-0013-3
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Recently, the role of small heat shock proteins (HSPs) has been widely recognized in cancer research. Small HSPs are tumor-protective via numerous, independent mechanisms such as: oxidative stress, protection preventing protein denaturation, anti-apoptotic activity, and likely direct suppression of the immune system. However, it is unclear whether they play any role in the initial steps in carcinogenesis. This article seeks to familiarize the reader with general characteristics of small HSPs (especially HSP-27, alpha A/B-crystallins), their tissue distribution with special regard on expression in malignant specimens, and biological properties of intracellular HSP-27 and alpha A/B-crystallins promoting tumor genesis and growth. A separate chapter describes immunomodulatory characteristics of extracellular HSP-27 with special emphasis on their plausible effect on the neoplasm development.
引用
收藏
页码：103 / 111
页数：9
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