Opportunities and methods for studying alternative splicing in cancer with RNA-Seq

被引：75
|
作者：
Feng, Huijuan
Qin, Zhiyi
Zhang, Xuegong [1 ]
机构：
[1] Tsinghua Univ, Bioinformat Div, Ctr Synthet & Syst Biol, TNLIST, Beijing 100084, Peoples R China
来源：
CANCER LETTERS | 2013年 / 340卷 / 02期
关键词：
RNA-Seq; Alternative splicing; Cancer; Transcriptomes; Bioinformatics; SPLEEN TYROSINE KINASE; DIFFERENTIAL EXPRESSION ANALYSIS; GENE-EXPRESSION; PROSTATE-CANCER; INTEGRATIVE ANALYSIS; WHOLE-TRANSCRIPTOME; ISOFORM EXPRESSION; NONCODING RNAS; FUSIONS; IDENTIFICATION;
D O I：
10.1016/j.canlet.2012.11.010
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The biogenesis, development and metastases of cancer are associated with many variations in the transcriptome. Alternative splicing of genes is a major post-transcriptional regulation mechanism that is involved in many types of cancer. The next-generation sequencing applied on RNAs (RNA-Seq) provides a new technology for studying transcriptomes. It provides an unprecedented opportunity for quantitatively studying alternative splicing in a systematic way. This mini-review summarizes the current RNA-Seq studies on cancer transcriptomes especially studies on cancer-related alternative splicing, and discusses the strategy for quantitative study of alternative splicing in cancers with RNA-Seq, the bioinformatics methods available and existing questions. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：179 / 191
页数：13
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