Anticonvulsant hypersensitivity syndrome

被引：37

作者：

Kaur, S ^{[1
]}

Sarkar, R ^{[1
]}

Thami, GP ^{[1
]}

Kanwar, AJ ^{[1
]}

机构：

[1] Govt Med Coll & Hosp, Dept Dermatol & Venerol, Chandigarh 160047, India

来源：

PEDIATRIC DERMATOLOGY | 2002年 / 19卷 / 02期

关键词：

D O I：

10.1046/j.1525-1470.2002.00045.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Anticonvulsant hypersensitivity syndrome is an acute, life-threatening, idiosyncratic drug reaction seen with the aromatic antiepileptic drugs, phenytoin, carbamazepine, phenobarbital, and primidone, with frequent cross sensitivity. It usually occurs 2-8 weeks after initiation of therapy and the hallmark clinical features are fever, rash, and lymphadenopathy. Hematologic abnormalities such as eosinophilia, atypical lymphocytes, and internal organ involvement also occur with varying severity. A case of hypersensitivity syndrome due to carbamazepine with cross sensitivity to phenytoin is reported. It is emphasized that this serious drug reaction with diverse clinical presentations should be recognized and treated promptly.

引用

页码：142 / 145

页数：4

共 14 条

[1] Drug-induced pseudolymphoma and drug hypersensitivity syndrome (Drug Rash with Eosinophilia and Systemic Symptoms: DRESS) [J].

Bocquet, H ;

Bagot, M ;

Roujeau, JC .

SEMINARS IN CUTANEOUS MEDICINE AND SURGERY, 1996, 15 (04) :250-257

[2]

BROWN YS, 1999, PEDIAT DERMATOL, V16, P460

[3] FAMILIAL OCCURRENCE OF HYPERSENSITIVITY TO PHENYTOIN [J].

GENNIS, MA ;

VEMURI, R ;

BURNS, EA ;

HILL, JV ;

MILLER, MA ;

SPIELBERG, SP .

AMERICAN JOURNAL OF MEDICINE, 1991, 91 (06) :631-634

[4] DRUG-INDUCED HYPOTHYROIDISM - THE THYROID AS A TARGET ORGAN IN HYPERSENSITIVITY REACTIONS TO ANTICONVULSANTS AND SULFONAMIDES [J].

GUPTA, A ;

EGGO, MC ;

UETRECHT, JP ;

CRIBB, AE ;

DANEMAN, D ;

RIEDER, MJ ;

SHEAR, NH ;

CANNON, M ;

SPIELBERG, SP .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 1992, 51 (01) :56-67

[5]

HAMMER HM, 1999, SEIZURE, V8, P190

[6] PHENYTOIN-INDUCED PSEUDOLYMPHOMA - A REPORT OF A CASE AND REVIEW OF THE LITERATURE [J].

HARRIS, DWS ;

OSTLERE, L ;

BUCKLEY, C ;

WHITTAKER, S ;

SWENY, P ;

RUSTIN, MHA .

BRITISH JOURNAL OF DERMATOLOGY, 1992, 127 (04) :403-406

[7] Lamotrigine overdose presenting as anticonvulsant hypersensitivity syndrome [J].

Mylonakis, E ;

Vittorio, CC ;

Hollik, DA ;

Rounds, S .

ANNALS OF PHARMACOTHERAPY, 1999, 33 (05) :557-559

[8]

ROUJEAU JC, 1994, NEW ENGL J MED, V331, P1275

[9]

SALTZSTEIN SL, 1959, CANCER-AM CANCER SOC, V12, P164, DOI 10.1002/1097-0142(195901/02)12:1<164::AID-CNCR2820120122>3.0.CO

[10]

2-Y

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