BRAF Inhibitor-Driven Tumor Proliferation in a KRAS-Mutated Colon Carcinoma Is Not Overcome by MEK1/2 Inhibition

被引:43
作者
Andrews, Miles C. [1 ]
Behren, Andreas [2 ]
Chionh, Fiona [2 ]
Mariadason, John [2 ]
Vella, Laura J. [2 ]
Do, Hongdo [3 ]
Dobrovic, Alexander [3 ]
Tebbutt, Niall [1 ]
Cebon, Jonathan [1 ]
机构
[1] Austin Hlth, Joint Ludwig Austin Oncol Unit, Melbourne, Vic, Australia
[2] Ludwig Inst Canc Res, Austin Branch, Melbourne, Vic, Australia
[3] Peter MacCallum Canc Ctr, Melbourne, Vic, Australia
基金
英国医学研究理事会;
关键词
SQUAMOUS-CELL CARCINOMAS; ADVANCED MELANOMA; RAF INHIBITORS; MUTATIONS; SURVIVAL; V600E;
D O I
10.1200/JCO.2013.50.4118
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
[No abstract available]
引用
收藏
页码:E448 / E451
页数:4
相关论文
共 11 条
  • [1] Progression of RAS-Mutant Leukemia during RAF Inhibitor Treatment
    Callahan, Margaret K.
    Rampal, Raajit
    Harding, James J.
    Klimek, Virginia M.
    Chung, Young Rock
    Merghoub, Taha
    Wolchok, Jedd D.
    Solit, David B.
    Rosen, Neal
    Abdel-Wahab, Omar
    Levine, Ross L.
    Chapman, Paul B.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2012, 367 (24) : 2316 - 2321
  • [2] Activity of the oral MEK inhibitor trametinib in patients with advanced melanoma: a phase 1 dose-escalation trial
    Falchook, Gerald S.
    Lewis, Karl D.
    Infante, Jeffrey R.
    Gordon, Michael S.
    Vogelzang, Nicholas J.
    DeMarini, Douglas J.
    Sun, Peng
    Moy, Christopher
    Szabo, Stephen A.
    Roadcap, Lori T.
    Peddareddigari, Vijay G. R.
    Lebowitz, Peter F.
    Le, Ngocdiep T.
    Burris, Howard A., III
    Messersmith, Wells A.
    O'Dwyer, Peter J.
    Kim, Kevin B.
    Flaherty, Keith
    Bendell, Johanna C.
    Gonzalez, Rene
    Kurzrock, Razelle
    Fecher, Leslie A.
    [J]. LANCET ONCOLOGY, 2012, 13 (08) : 782 - 789
  • [3] Combined BRAF and MEK Inhibition in Melanoma with BRAF V600 Mutations
    Flaherty, Keith T.
    Infante, Jeffery R.
    Daud, Adil
    Gonzalez, Rene
    Kefford, Richard F.
    Sosman, Jeffrey
    Hamid, Omid
    Schuchter, Lynn
    Cebon, Jonathan
    Ibrahim, Nageatte
    Kudchadkar, Ragini
    Burris, Howard A., III
    Falchook, Gerald
    Algazi, Alain
    Lewis, Karl
    Long, Georgina V.
    Puzanov, Igor
    Lebowitz, Peter
    Singh, Ajay
    Little, Shonda
    Sun, Peng
    Allred, Alicia
    Ouellet, Daniele
    Kim, Kevin B.
    Patel, Kiran
    Weber, Jeffrey
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2012, 367 (18) : 1694 - 1703
  • [4] Improved Survival with MEK Inhibition in BRAF-Mutated Melanoma
    Flaherty, Keith T.
    Robert, Caroline
    Hersey, Peter
    Nathan, Paul
    Garbe, Claus
    Milhem, Mohammed
    Demidov, Lev V.
    Hassel, Jessica C.
    Rutkowski, Piotr
    Mohr, Peter
    Dummer, Reinhard
    Trefzer, Uwe
    Larkin, James M. G.
    Utikal, Jochen
    Dreno, Brigitte
    Nyakas, Marta
    Middleton, Mark R.
    Becker, Juergen C.
    Casey, Michelle
    Sherman, Laurie J.
    Wu, Frank S.
    Ouellet, Daniele
    Martin, Anne-Marie
    Patel, Kiran
    Schadendorf, Dirk
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2012, 367 (02) : 107 - 114
  • [5] Induction of Cutaneous Squamous Cell Carcinomas by RAF Inhibitors: Cause for Concern?
    Lacouture, Mario E.
    O'Reilly, Kathryn
    Rosen, Neal
    Solit, David B.
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (03) : 329 - 330
  • [6] Distinguishing Clinicopathologic Features of Patients with V600E and V600K BRAF-Mutant Metastatic Melanoma
    Menzies, Alexander M.
    Haydu, Lauren E.
    Visintin, Lydia
    Carlino, Matteo S.
    Howle, Julie R.
    Thompson, John F.
    Kefford, Richard F.
    Scolyer, Richard A.
    Long, Georgina V.
    [J]. CLINICAL CANCER RESEARCH, 2012, 18 (12) : 3242 - 3249
  • [7] RAS Mutations Are Associated With the Development of Cutaneous Squamous Cell Tumors in Patients Treated With RAF Inhibitors
    Oberholzer, Patrick A.
    Kee, Damien
    Dziunycz, Piotr
    Sucker, Antje
    Kamsukom, Nyam
    Jones, Robert
    Roden, Christine
    Chalk, Clinton J.
    Ardlie, Kristin
    Palescandolo, Emanuele
    Piris, Adriano
    MacConaill, Laura E.
    Robert, Caroline
    Hofbauer, Guenther F. L.
    McArthur, Grant A.
    Schadendorf, Dirk
    Garraway, Levi A.
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (03) : 316 - 321
  • [8] Satyamoorthy K, 2003, CANCER RES, V63, P756
  • [9] Prevalence of BRAF V600E mutation in Chinese melanoma patients: Large scale analysis of BRAF and NRAS mutations in a 432-case cohort
    Si, Lu
    Kong, Yan
    Xu, Xiaowei
    Flaherty, Keith T.
    Sheng, Xinan
    Cui, Chuanliang
    Chi, Zhihong
    Li, Siming
    Mao, Lili
    Guo, Jun
    [J]. EUROPEAN JOURNAL OF CANCER, 2012, 48 (01) : 94 - 100
  • [10] Survival in BRAF V600-Mutant Advanced Melanoma Treated with Vemurafenib
    Sosman, Jeffrey A.
    Kim, Kevin B.
    Schuchter, Lynn
    Gonzalez, Rene
    Pavlick, Anna C.
    Weber, Jeffrey S.
    McArthur, Grant A.
    Hutson, Thomas E.
    Moschos, Stergios J.
    Flaherty, Keith T.
    Hersey, Peter
    Kefford, Richard
    Lawrence, Donald
    Puzanov, Igor
    Lewis, Karl D.
    Amaravadi, Ravi K.
    Chmielowski, Bartosz
    Lawrence, H. Jeffrey
    Shyr, Yu
    Ye, Fei
    Li, Jiang
    Nolop, Keith B.
    Lee, Richard J.
    Joe, Andrew K.
    Ribas, Antoni
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2012, 366 (08) : 707 - 714