Insulin and Growth Hormone Balance: Implications for Obesity

被引：59

作者：

Huang, Zhengxiang ^{[1
]}

Huang, Lili ^{[1
]}

Waters, Michael J. ^{[2
]}

Chen, Chen ^{[1
]}

机构：

[1] Univ Queensland, Sch Biomed Sci, Brisbane, Qld, Australia

[2] Univ Queensland, Inst Mol Biosci, Brisbane, Qld, Australia

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2020年 / 31卷 / 09期

基金：

澳大利亚国家健康与医学研究理事会;

关键词：

POLYCYSTIC-OVARY-SYNDROME; OBSTRUCTIVE SLEEP-APNEA; WHITE ADIPOSE-TISSUES; BODY-FAT DISTRIBUTION; DIET-INDUCED OBESITY; ENERGY-EXPENDITURE; SKELETAL-MUSCLE; WEIGHT-LOSS; PHOSPHATIDYLINOSITOL; 3-KINASE; TYROSINE PHOSPHORYLATION;

D O I：

10.1016/j.tem.2020.04.005

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Disruption of endocrine hormonal balance (i.e., increased levels of insulin, and reduced levels of growth hormone, GH) often occurs in pre-obesity and obesity. Using distinct intracellular signaling pathways to control cell and body metabo-lism, GH and insulin also regulate each other's secretion to maintain overall metabolic homeostasis. Therefore, a comprehensive understanding of insulin and GH balance is essential for understanding endocrine hormonal contributions to energy storage and utilization. In this review we summarize the actions of, and interactions between, insulin and GH at the cellular level, and highlight the associ-ation between the insulin/GH ratio and energy metabolism, as well as fat accumu-lation. Use of the [insulin]:[GH] ratio as a biomarker for predicting the development of obesity is proposed.

引用

页码：642 / 654

页数：13

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