L-asparaginase and venous thromboembolism in acute lymphocytic leukemia

被引：41

作者：

Goyal, Gaurav ^{[1
]}

Bhatt, Vijaya Raj ^{[2
]}

机构：

[1] Creighton Univ, Sch Med, Dept Internal Med, Omaha, NE 68178 USA

[2] Univ Nebraska Med Ctr, Div Hematol Oncol, Dept Internal Med, Omaha, NE 68198 USA

来源：

FUTURE ONCOLOGY | 2015年 / 11卷 / 17期

关键词：

acute lymphocytic leukemia; asparaginase; thrombosis; venous thromboembolism; ACUTE LYMPHOBLASTIC-LEUKEMIA; MOLECULAR-WEIGHT HEPARIN; ESCHERICHIA-COLI-ASPARAGINASE; ANTITHROMBIN-III; ERWINIA-ASPARAGINASE; HIGHER-RISK; CHILDREN; THROMBOSIS; CANCER; PREVENTION;

D O I：

10.2217/fon.15.114

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The occurrence of venous thromboembolism (VTE) in acute lymphocytic leukemia patients receiving L-asparaginase therapy may cause significant morbidity, neurological sequela and possibly worse outcomes. The prophylactic use of antithrombin infusion (to keep antithrombin activity >60%) or low molecular weight heparin (LMWH) may reduce the risk of VTE. The decision to continue L-asparaginase therapy after the development of VTE should be based on anticipated benefits, severity of VTE and the ability to continue therapeutic anticoagulation. In patients receiving asparaginase rechallenge, the use of therapeutic LMWH, monitoring of anti-Xa level and antithrombin level are important. Novel oral anticoagulants are not dependent on antithrombin level, hence offer theoretical advantages over LMWH for the prevention and therapy of asparaginase-related VTE.

引用

页码：2459 / 2470

页数：12

共 48 条

[1] The impact of prophylactic fresh-frozen plasma and cryoprecipitate on the incidence of central nervous system thrombosis and hemorrhage in children with acute lymphoblastic leukemia receiving asparaginase [J].

Abbott, Lesleigh S. ;

Deevska, Mariana ;

Fernandez, Conrad V. ;

Dix, David ;

Price, Victoria E. ;

Wang, Hao ;

Parker, Louise ;

Yhap, Margaret ;

Fitzgerald, Colleen ;

Barnard, Dorothy R. ;

Berman, Jason N. .

BLOOD, 2009, 114 (25) :5146-5151

[2] Anticoagulation for the long-term treatment of venous thromboembolism in patients with cancer [J].

Akl, Elie A. ;

Kahale, Lara ;

Barba, Maddalena ;

Neumann, Ignacio ;

Labedi, Nawman ;

Terrenato, Irene ;

Sperati, Francesca ;

Muti, Paola ;

Schuenemann, Holger .

COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2014, (07)

[3] Anticoagulation for the initial treatment of venous thromboembolism in patients with cancer [J].

Akl, Elie A. ;

Kahale, Lara ;

Neumann, Ignacio ;

Barba, Maddalena ;

Sperati, Francesca ;

Terrenato, Irene ;

Muti, Paola ;

Schuenemann, Holger .

COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2014, (06)

[4]

Asselin BL, 1999, ADV EXP MED BIOL, V457, P621

[5] A randomized comparison of native Escherichia coli asparaginase and polyethylene glycol conjugated asparaginase for treatment of children with newly diagnosed standard-risk acute lymphoblastic leukemia:: a Children's Cancer Group study [J].

Avramis, VI ;

Sencer, S ;

Periclou, AP ;

Sather, H ;

Bostrom, BC ;

Cohen, LJ ;

Ettinger, AG ;

Ettinger, LJ ;

Franklin, J ;

Gaynon, PS ;

Hilden, JM ;

Lange, B ;

Majlessipour, F ;

Mathew, P ;

Needle, M ;

Neglia, J ;

Reaman, G ;

Holcenberg, JS .

BLOOD, 2002, 99 (06) :1986-1994

[6] Insight into the mechanism of asparaginase-induced depletion of antithrombin III in treatment of childhood acute lymphoblastic leukemia [J].

Bushman, JE ;

Palmieri, D ;

Whinna, HC ;

Church, FC .

LEUKEMIA RESEARCH, 2000, 24 (07) :559-565

[7] Thrombotic complications in childhood acute lymphoblastic leukemia: a meta-analysis of 17 prospective studies comprising 1752 pediatric patients [J].

Caruso, Vanesa ;

Iacoviello, Licia ;

Di Castelnuovo, Augusto ;

Storti, Sergio ;

Mariani, Guglielmo ;

de Gaetano, Giovanni ;

Donati, Maria Benedetta .

BLOOD, 2006, 108 (07) :2216-2222

[8] Risk of venous thromboembolism associated with peripherally inserted central catheters: a systematic review and meta-analysis [J].

Chopra, Vineet ;

Anand, Sarah ;

Hickner, Andy ;

Buist, Michael ;

Rogers, Mary A. M. ;

Saint, Sanjay ;

Flanders, Scott A. .

LANCET, 2013, 382 (9889) :311-325

[9]

Cory JG, 2006, IN VIVO, V20, P587

[10] L-asparaginase loaded red blood cells in refractory or relapsing acute lymphoblastic leukaemia in children and adults: results of the GRASPALL 2005-01 randomized trial [J].

Domenech, Carine ;

Thomas, Xavier ;

Chabaud, Sylvie ;

Baruchel, Andre ;

Gueyffier, Francois ;

Mazingue, Francoise ;

Auvrignon, Anne ;

Corm, Selim ;

Dombret, Herve ;

Chevallier, Patrice ;

Galambrun, Claire ;

Huguet, Francoise ;

Legrand, Faezeh ;

Mechinaud, Francoise ;

Vey, Norbert ;

Philip, Irene ;

Liens, David ;

Godfrin, Yann ;

Rigal, Dominique ;

Bertrand, Yves .

BRITISH JOURNAL OF HAEMATOLOGY, 2011, 153 (01) :58-65

← 1 2 3 4 5 →