Rh(III)-Catalyzed Synthesis of Multisubstituted Isoquinoline and Pyridine N-Oxides from Oximes and Diazo Compounds

被引：402

作者：

Shi, Zhuangzhi ^{[1
]}

Koester, Dennis C. ^{[1
]}

Boultadakis-Arapinis, Melissa ^{[1
]}

Glorius, Frank ^{[1
]}

机构：

[1] Univ Munster, Inst Organ Chem, D-48149 Munster, Germany

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2013年 / 135卷 / 33期

基金：

欧洲研究理事会;

关键词：

C-H BONDS; ONE-POT SYNTHESIS; ALPHA; BETA-UNSATURATED KETOXIMES; RHODIUM(III)-CATALYZED SYNTHESIS; REGIOSELECTIVE SYNTHESIS; INTERNAL ALKYNES; DIRECT ARYLATION; FUNCTIONALIZATION; ACTIVATION; ARYL;

D O I：

10.1021/ja406338r

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Multisubstituted isoquinoline and pyridine N-oxides have been prepared by Rh(III)-catalyzed cyclization of oximes and diazo compounds via aryl and vinylic C-H activation. This intermolecular annulation involving tandem C-H activation, cyclization, and condensation steps proceeds under mild conditions, obviates the need for oxidants, releases N-2 and H2O as the byproducts, and displays a broad substituent scope.

引用

页码：12204 / 12207

页数：4

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