Analysis of opioid receptor subtype antagonist effects upon mu opioid agonist-induced feeding elicited from the ventral tegmental area of rats

被引：26

作者：

Lamonte, N ^{[1
]}

Echo, JA ^{[1
]}

Ackerman, TF ^{[1
]}

Christian, G ^{[1
]}

Bodnar, RJ ^{[1
]}

机构：

[1] CUNY Queens Coll, Dept Psychol & Neuropsychol Doctoral SubProgram, Flushing, NY 11367 USA

来源：

BRAIN RESEARCH | 2002年 / 929卷 / 01期

基金：

美国国家科学基金会;

关键词：

feeding; DAMGO; ventral tegmental area; opioid antagonist; Mu opioid receptor; kappa opioid receptor; delta opioid receptor;

D O I：

10.1016/S0006-8993(01)03382-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The present study examined opioid receptor(s) mediation of feeding elicited by mu opioid agonists in the ventral tegmental area using general or selective opioid antagonist pretreatment. Naltrexone as well as equimolar doses of selective mu and kappa, but not delta opioid antagonists in the ventral tegmental area significantly reduced mu agonist-induced feeding, indicating a pivotal role for these receptor subtypes in the full expression of this response. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：96 / 100

页数：5

共 24 条

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