Low cytotoxicity rhodamine-based fluorescent probes for Fe(III) and their application in living cells

被引：21

作者：

Liu, Xiao-Jing ^{[1
]}

Zhang, Ming ^{[1
]}

Yang, Mei-Pan ^{[1
]}

Li, Bo ^{[1
]}

Cheng, Zhao ^{[2
]}

Yang, Bing-Qin ^{[1
]}

机构：

[1] Northwest Univ, Coll Chem & Mat Sci, Key Lab Synthet & Nat Funct Mol Chem, Minist Educ, Xian 710127, Shaanxi, Peoples R China

[2] Xian Med Univ, Sch Pharmaceut Sci, Xian 710021, Shaanxi, Peoples R China

来源：

TETRAHEDRON | 2015年 / 71卷 / 42期

基金：

中国国家自然科学基金;

关键词：

Rhodamine B; Fluorescent probe; Recognition; Low toxicity; Live cell imaging; IRON; CHEMOSENSOR; FE3+; IRON(III); COUMARIN;

D O I：

10.1016/j.tet.2015.08.031

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two novel rhodamine-active probes G2 and R2 were designed and synthesized, which adopted a 1:1 binding stoichiometry and showed highly selective sensing for Fe3+ ions over other metal ions in EtOH-H2O (1:1, v/v, Tris-HCl pH=7.4) in the fluorescence and ultraviolet spectra. Cytotoxicity and bioimaging studies by PC12 and L929 indicated that the probes were low cytotoxic, cell permeable and suitable for detecting Fe3+ in living cells. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：8194 / 8199

页数：6

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