Feedback determines the structure of correlated variability in primary visual cortex

被引:89
作者
Bondy, Adrian G. [1 ,2 ]
Haefner, Ralf M. [3 ]
Cumming, Bruce G. [1 ]
机构
[1] NEI, Sensorimotor Res Lab, NIH, Bldg 10, Bethesda, MD 20892 USA
[2] Brown NIH Neurosci Grad Partnership Program, Providence, RI 02912 USA
[3] Univ Rochester, Ctr Visual Sci, Brain & Cognit Sci, Rochester, NY 14627 USA
关键词
DECISION-RELATED ACTIVITY; SENSORY NEURONS; CHOICE-PROBABILITIES; AREA MT; POPULATION CODE; ATTENTION; MACAQUE; RESPONSES; BEHAVIOR; INFORMATION;
D O I
10.1038/s41593-018-0089-1
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The variable responses of sensory neurons tend to be weakly correlated (spike-count correlation, r(sc)). This is widely thought to reflect noise in shared afferents, in which case r(sc) can limit the reliability of sensory coding. However, it could also be due to feedback from higher-order brain regions. Currently, the relative contributions of these sources are unknown. We addressed this by recording from populations of V1 neurons in macaques performing different discrimination tasks involving the same visual input. We found that the structure of r(sc) (the way r(sc) varied with neuronal stimulus preference) changed systematically with task instruction. Therefore, even at the earliest stage in the cortical visual hierarchy, r(sc) structure during task performance primarily reflects feedback dynamics. Consequently, previous proposals for how r(sc) constrains sensory processing need not apply. Furthermore, we show that correlations between the activity of single neurons and choice depend on feedback engaged by the task.
引用
收藏
页码:598 / +
页数:12
相关论文
共 55 条
[1]   The effect of correlated variability on the accuracy of a population code [J].
Abbott, LF ;
Dayan, P .
NEURAL COMPUTATION, 1999, 11 (01) :91-101
[2]  
Ahumada AJ, 1996, PERCEPTION, V25, P2, DOI [10.1068/v9610501, DOI 10.1068/V9610501]
[3]  
[Anonymous], 1867, Handbuch der physiologischen Optik
[4]   Neural correlations, population coding and computation [J].
Averbeck, BB ;
Latham, PE ;
Pouget, A .
NATURE REVIEWS NEUROSCIENCE, 2006, 7 (05) :358-366
[5]   Correlated firing in macaque visual area MT: Time scales and relationship to behavior [J].
Bair, W ;
Zohary, E ;
Newsome, WT .
JOURNAL OF NEUROSCIENCE, 2001, 21 (05) :1676-1697
[6]   A relationship between behavioral choice and the visual responses of neurons in macaque MT [J].
Britten, KH ;
Newsome, WT ;
Shadlen, MN ;
Celebrini, S ;
Movshon, JA .
VISUAL NEUROSCIENCE, 1996, 13 (01) :87-100
[7]   VISUAL SIGNAL-DETECTION .4. OBSERVER INCONSISTENCY [J].
BURGESS, AE ;
COLBORNE, B .
JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION, 1988, 5 (04) :617-627
[8]   Feedforward, feedback and inhibitory connections in primate visual cortex [J].
Callaway, EM .
NEURAL NETWORKS, 2004, 17 (5-6) :625-632
[9]   Stimulus onset quenches neural variability: a widespread cortical phenomenon [J].
Churchland, Mark M. ;
Yu, Byron M. ;
Cunningham, John P. ;
Sugrue, Leo P. ;
Cohen, Marlene R. ;
Corrado, Greg S. ;
Newsome, William T. ;
Clark, Andrew M. ;
Hosseini, Paymon ;
Scott, Benjamin B. ;
Bradley, David C. ;
Smith, Matthew A. ;
Kohn, Adam ;
Movshon, J. Anthony ;
Armstrong, Katherine M. ;
Moore, Tirin ;
Chang, Steve W. ;
Snyder, Lawrence H. ;
Lisberger, Stephen G. ;
Priebe, Nicholas J. ;
Finn, Ian M. ;
Ferster, David ;
Ryu, Stephen I. ;
Santhanam, Gopal ;
Sahani, Maneesh ;
Shenoy, Krishna V. .
NATURE NEUROSCIENCE, 2010, 13 (03) :369-U25
[10]   Context-Dependent Changes in Functional Circuitry in Visual Area MT [J].
Cohen, Marlene R. ;
Newsome, William T. .
NEURON, 2008, 60 (01) :162-173