Synthesis and Biological Evaluation of Potent Antifungal Agents

被引：27

作者：

Geronikaki, Athina ^{[1
]}

Fesatidou, Maria ^{[1
]}

Kartsev, Victor ^{[2
]}

Macaev, Fliur ^{[3
]}

机构：

[1] Aristotle Univ Thessaloniki, Sch Pharm, Thessaloniki 54124, Greece

[2] InterBioscreen, Moscow, Russia

[3] Moldavian Acad Sci, Inst Chem, MD-2028 Kishinev, Moldova

来源：

CURRENT TOPICS IN MEDICINAL CHEMISTRY | 2013年 / 13卷 / 21期

关键词：

Allylamines; antifungal; Aspergillosis; azoles; Candidiasis; thiazoles; thiazolidinones; thiophenes; FUNGAL N-MYRISTOYLTRANSFERASE; LOCAL-ANESTHETIC ACTIVITY; IN-VITRO ANTIBACTERIAL; ANTIMICROBIAL ACTIVITY; LANOSTEROL; 14-ALPHA-DEMETHYLASE; 1,4-NAPHTHOQUINONE DERIVATIVES; ANTIINFLAMMATORY ACTIVITY; CANDIDA-ALBICANS; ANTI-HIV; THIAZOLIDINONE DERIVATIVES;

D O I：

10.2174/15680266113136660195

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The last two decades are characterized by major increases in the incidence of systemic fungal infections caused by the yeast Candida albicans, particularly in immunocompromised patients. On the other hand it was observed the increased number of pathogenic microorganisms with multiple resistance to drugs. Also there is a big variety of drugs for the treatment of candidiasis, only two drugs are used for the treatment of infections from Aspergillus fumigatus. Taking into account that the long term therapy with azoles results in resistance a critical need exists for new antifungal agents with fewer side effecgts to treat these life-threatening fungal infections. This review will cover the advances in research of biological activity of different compounds from different chemical classes with focus on their antifungal properties.

引用

页码：2684 / 2733

页数：50

共 342 条

[1] Utilization of α-halocarbonyl compounds in the synthesis of thiazole, thiadiazole, and thiophene derivatives [J].

Abdel-Latif, Ehab ;

Bondock, Samir .

HETEROATOM CHEMISTRY, 2006, 17 (04) :299-305

[2] Synthesis and antimicrobial evaluation of 1-(benzofuran-2-yl)-4-nitro-3-arylbutan-1-ones and 3-(benzofuran-2-yl)-4,5-dihydro-5-aryl-1-[4-(aryl)-1, 3-thiazol-2-yl]-1H-pyrazoles [J].

Abdel-Wahab, Bakr F. ;

Abdel-Aziz, Hatem A. ;

Ahmed, Essam M. .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2009, 44 (06) :2632-2635

[3]

Abhinit M., 2009, INT J PHARM PHARM SC, V1, P47

[4] Synthesis, spectral studies and antiamoebic activity of new 1-N-substituted thiocarbamoyl-3-phenyl-2-pyrazolines [J].

Abid, Mohammad ;

Bhat, Abdul Roouf ;

Athar, Fareeda ;

Azam, Amir .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2009, 44 (01) :417-425

[5]

Ablordeppey SY, 1999, CURR MED CHEM, V6, P1151

[6]

Agarwal N, 1997, INDIAN J HETEROCY CH, V6, P291

[7] Synthesis and biological evaluation of some 2,4,5-trisubstituted thiazole derivatives as potential antimicrobial and anticancer agents [J].

Al-Saadi, Mohammed S. ;

Faidallah, Hassan M. ;

Rostom, Sherif A. F. .

ARCHIV DER PHARMAZIE, 2008, 341 (07) :424-434

[8] Anti-breast cancer activity of some novel 1,2-dihydropyridine, thiophene and thiazole derivatives [J].

Al-Said, Mansour S. ;

Bashandy, Mahmoud S. ;

Al-Qasoumi, Saleh I. ;

Ghorab, Mostafa M. .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2011, 46 (01) :137-141

[9] Synthesis, structural activity relationship and anti-tubercular activity of novel pyrazoline derivatives [J].

Ali, Mohamed Ashraf ;

Shaharyar, Mohammad ;

Siddiqui, Anees Ahamed .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2007, 42 (02) :268-275

[10]

Ananthanarayan R., 2006, TXB MICROBIOLOGY, P39

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