The Cardiac Microvasculature in Hypertension, Cardiac Hypertrophy and Diastolic Heart Failure

被引：66
|
作者：
Hoenig, Michel R. [1 ]
Bianchi, Cesario [2 ,3 ]
Rosenzweig, Anthony [3 ,4 ]
Sellke, Frank W. [2 ,3 ]
机构：
[1] Royal Brisbane & Womens Hosp, Brisbane, Qld, Australia
[2] Beth Israel Deaconess Med Ctr, Dept Surg, Cardiothorac Res Lab, Boston, MA 02215 USA
[3] Harvard Univ, Sch Med, Boston, MA USA
[4] Beth Israel Deaconess Med Ctr, Dept Med, Div Cardiovasc, Boston, MA 02215 USA
来源：
CURRENT VASCULAR PHARMACOLOGY | 2008年 / 6卷 / 04期
关键词：
Endothelial progenitor cell; angiogenesis; neovascularization; hypoxia inducible factor; heart failure; hypertension; diabetes; microvasculature;
D O I：
10.2174/157016108785909779
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Recent studies revealed an exceedingly high mortality with diastolic heart failure that was previously regarded as relatively benign compared to systolic heart failure. Prominent risk factors for diastolic heart failure are increasing age, hypertension and diabetes. These risk factors are associated with coronary microvascular rarefaction and resultant decreased coronary flow reserve, thereby rendering the myocardium vulnerable to ischemia. We discuss the importance of angiogenic gene programming in preserving the coronary microvasculature, preserving cardiac function and altering disease course. Further, we discuss the possible utility of therapies that activate hypoxia inducible factor-1 in preventing rarefaction of the coronary microvasculature and maintaining cardiac diastolic function.
引用
收藏
页码：292 / 300
页数：9
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