Evolving treatment options for melanoma brain metastases

被引：77

作者：

Ajithkumar, Thankamma ^{[1
]}

Parkinson, Christine ^{[1
]}

Fife, Kate ^{[1
]}

Corrie, Pippa ^{[1
]}

Jeff, Sarah ^{[1
]}

机构：

[1] Cambridge Univ Hosp Natl Hlth Serv Fdn Trust, Dept Oncol, Cambridge CB2 OQQ, England

来源：

LANCET ONCOLOGY | 2015年 / 16卷 / 13期

关键词：

MALIGNANT-MELANOMA; RADIATION-THERAPY; OPEN-LABEL; RANDOMIZED-TRIAL; CEREBRAL METASTASES; SINGLE METASTASES; POSITIVE MELANOMA; PHASE-II; IPILIMUMAB; RADIOTHERAPY;

D O I：

10.1016/S1470-2045(15)00141-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Melanoma is a leading cause of lost productivity due to premature cancer mortality. Melanoma frequently spreads to the brain and is associated with rapid deterioration in quality and quantity of life. Until now, treatment options have been restricted to surgery and radiotherapy, although neither modality has been well studied in clinical trials. However, the new immune checkpoint inhibitors and molecularly targeted agents that have been introduced for treatment of metastatic melanoma are active against brain metastases and off er new opportunities to improve disease outcomes. New challenges arise, including how to integrate or sequence multiple treatment modalities, and current practice varies widely. In this Review, we summarise evidence for the treatment of melanoma brain metastases, and discuss the rationale and evidence for combination modalities, highlighting areas for future research.

引用

页码：E486 / E497

页数：12

共 83 条

[1] Ipilimumab in the real world: the UK expanded access programme experience in previously treated advanced melanoma patients [J].

Ahmad, Saif S. ;

Qian, Wendi ;

Ellis, Sarah ;

Mason, Elaine ;

Khattak, Muhammad A. ;

Gupta, Avinash ;

Shaw, Heather ;

Quinton, Amy ;

Kovarikova, Jarmila ;

Thillai, Kiruthikah ;

Rao, Ankit ;

Board, Ruth ;

Nobes, Jenny ;

Dalgleish, Angus ;

Grumett, Simon ;

Maraveyas, Anthony ;

Danson, Sarah ;

Talbot, Toby ;

Harries, Mark ;

Marples, Maria ;

Plummer, Ruth ;

Kumar, Satish ;

Nathan, Paul ;

Middleton, Mark R. ;

Larkin, James ;

Lorigan, Paul ;

Wheater, Matthew ;

Ottensmeier, Christian H. ;

Corrie, Pippa G. .

MELANOMA RESEARCH, 2015, 25 (05) :432-442

[2]

AMER MH, 1978, CANCER-AM CANCER SOC, V42, P660, DOI 10.1002/1097-0142(197808)42:2<660::AID-CNCR2820420237>3.0.CO

[3]

2-E

[4] Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial [J].

Andrews, DW ;

Scott, CB ;

Sperduto, PW ;

Flanders, AE ;

Gaspar, LE ;

Schell, MC ;

Werner-Wasik, M ;

Demas, W ;

Ryu, J ;

Bahary, JP ;

Souhami, L ;

Rotman, M ;

Mehta, MP ;

Curran, WJ .

LANCET, 2004, 363 (9422) :1665-1672

[5] A multiinstitutional outcome and prognostic factor analysis of radiosurgery for resectable single brain metastasis [J].

Auchter, RM ;

Lamond, JP ;

Alexander, E ;

Buatti, JM ;

Chappell, R ;

Friedman, WA ;

Kinsella, TJ ;

Levin, AB ;

Noyes, WR ;

Schultz, CJ ;

Loeffler, JS ;

Mehta, MP .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1996, 35 (01) :27-35

[6] Fotemustine compared with dacarbazine in patients with disseminated malignant melanoma:: A phase III study [J].

Avril, MF ;

Aamdal, S ;

Grob, JJ ;

Hauschild, A ;

Mohr, P ;

Bonerandi, JJ ;

Weichenthal, M ;

Neuber, K ;

Bieber, T ;

Gilde, K ;

Porta, VG ;

Fra, J ;

Bonneterre, J ;

Saïag, P ;

Kamanabrou, D ;

Pehamberger, H ;

Sufliarsky, J ;

Larriba, JLG ;

Scherrer, A ;

Menu, Y .

JOURNAL OF CLINICAL ONCOLOGY, 2004, 22 (06) :1118-1125

[7] Patterns of Response and Progression in Patients With BRAF-Mutant Melanoma Metastatic to the Brain Who Were Treated With Dabrafenib [J].

Azer, Mary W. F. ;

Menzies, Alexander M. ;

Haydu, Lauren E. ;

Kefford, Richard F. ;

Long, Georgina V. .

CANCER, 2014, 120 (04) :530-536

[8] Predictive Factors for the Development of Brain Metastasis in Advanced Unresectable Metastatic Melanoma [J].

Bedikian, Agop Y. ;

Wei, Caimiao ;

Detry, Michelle ;

Kim, Kevin B. ;

Papadopoulos, Nicholas E. ;

Hwu, Wen-Jen ;

Homsi, Jade ;

Davies, Michael ;

McIntyre, Susan ;

Hwu, Patrick .

AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS, 2011, 34 (06) :603-610

[9] PALLIATION OF BRAIN METASTASES - FINAL RESULTS OF THE 1ST 2 STUDIES BY THE RADIATION-THERAPY-ONCOLOGY-GROUP [J].

BORGELT, B ;

GELBER, R ;

KRAMER, S ;

BRADY, LW ;

CHANG, CH ;

DAVIS, LW ;

PEREZ, CA ;

HENDRICKSON, FR .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1980, 6 (01) :1-9

[10] Vemurafenib and Radiosensitization [J].

Boussemart, Lise ;

Boivin, Catherine ;

Claveau, Joel ;

Tao, Yun Gan ;

Tomasic, Gorana ;

Routier, Emilie ;

Mateus, Christine ;

Deutsch, Eric ;

Robert, Caroline .

JAMA DERMATOLOGY, 2013, 149 (07) :855-857

← 1 2 3 4 5 6 7 8 9 →