HLA allele frequencies and susceptibility to COVID-19 in a group of 99 Italian patients

被引：111

作者：

Novelli, Antonio ^{[1
]}

Andreani, Marco ^{[2
]}

Biancolella, Michela ^{[3
,4
]}

Liberatoscioli, Laura ^{[4
]}

Passarelli, Chiara ^{[1
]}

Colona, Vito Luigi ^{[4
]}

Rogliani, Paola ^{[5
]}

Leonardis, Francesca ^{[6
]}

Campana, Andrea ^{[7
]}

Carsetti, Rita ^{[8
]}

Andreoni, Massimo ^{[9
,10
]}

Bernardini, Sergio ^{[11
]}

Novelli, Giuseppe ^{[11
,12
,13
,14
]}

Locatelli, Franco ^{[15
,16
]}

机构：

[1] IRCCS, Bambino Gesu Childrens Hosp, Lab Med Genet, Rome, Italy

[2] IRCCS, Bambino Gesu Childrens Hosp, Transplantat Immunogenet Lab, Viale Ferdinando Baldelli 38, I-00146 Rome, Italy

[3] Tor Vergata Univ Rome, Dept Biol, Rome, Italy

[4] Tor Vergata Hosp, Med Genet Lab, Rome, Italy

[5] Univ Roma Tor Vergata, Dept Expt Med, Unit Resp Med, Rome, Italy

[6] Tor Vergata Univ Hosp, Intens Care Unit, Rome, Italy

[7] IRCCS Bambino Gesu Childrens Hosp, Dept Pediat, Rome, Italy

[8] IRCCS, Bambino Gesu Childrens Hosp, Immunol Diag Unit, Immunol Res Area B Cell Dev Unit, Rome, Italy

[9] Univ Roma Tor Vergata, Dept Syst Med, Rome, Italy

[10] Policlin Tor Vergata, Infect Dis Clin, Rome, Italy

[11] Univ Roma Tor Vergata, Dept Expt Med & Biochem Sci, Rome, Italy

[12] Univ Nevada, Sch Med, Dept Pharmacol, Reno, NV 89557 USA

[13] Tor Vergata Univ Rome, Dept Biomed & Prevent, Rome, Italy

[14] IRCCS Neuromed, Pozzilli, Italy

[15] IRCCS, Bambino Gesu Childrens Hosp, Dept Haematol & Oncol, Rome, Italy

[16] Sapienza Univ Rome, Dept Paediat, Rome, Italy

来源：

HLA | 2020年 / 96卷 / 05期

关键词：

COVID-19; HLA; Disease susceptibility;

D O I：

10.1111/tan.14047

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

With the aim to individuate alleles that may reflect a higher susceptibility to the disease, in the present study we analyzed the HLA allele frequency distribution in a group of 99 Italian patients affected by a severe or extremely severe form of COVID-19. After the application of Bonferroni's correction for multiple tests, a significant association was found forHLA-DRB1*15:01, -DQB1*06:02and-B*27:07, after comparing the results to a reference group of 1017 Italian individuals, previously typed in our laboratory. The increased frequencies observed may contribute to identify potential markers of susceptibility to the disease, although controversial results on the role of single HLA alleles in COVID-19 patients have been recently reported.

引用

页码：610 / 614

页数：5

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