An Efficient and Facile Synthesis of 1H-Pyrazolo[1,2-b]phthalazine-5,10-dione Derivatives of Biological Interest

被引：22

作者：

Shah, Nimesh M. ^{[1
]}

Patel, Manish P. ^{[1
]}

Patel, Ranjan G. ^{[1
]}

机构：

[1] S P Univ, Dept Chem, Vallabh Vidyanagar 388120, Gujarat, India

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2012年 / 49卷 / 06期

关键词：

ONE-POT SYNTHESIS; ANTIBACTERIAL ACTIVITY; ANTIMICROBIAL ACTIVITY; MICROWAVE IRRADIATION; ANTIFUNGAL ACTIVITY; ARYLPHTHALAZINES; CYTOTOXICITY; INHIBITORS; DISCOVERY; SERIES;

D O I：

10.1002/jhet.918

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple and efficient method has been developed for the synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives through a one-pot three-component condensation reaction of 2-chloro-3-formyl quinolines, malononitrile/ethyl cyanoacetate and 2,3-dihydro-1,4-phthalazinedione using a catalytic amount of piperidine in refluxing ethanol. All the synthesized compounds were screened for their antibacterial activity against a panel of pathogenic strains of bacteria and fungi.

引用

页码：1310 / 1316

页数：7

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