The role of PML in tumor suppression

被引：460
作者：
Salomoni, P
Pandolfi, PP
机构：
[1] Mem Sloan Kettering Canc Ctr, Sloan Kettering Inst, Program Mol Biol, New York, NY 10021 USA
[2] Mem Sloan Kettering Canc Ctr, Sloan Kettering Inst, Dept Pathol, New York, NY 10021 USA
来源：
CELL | 2002年 / 108卷 / 02期
关键词：
D O I：
10.1016/S0092-8674(02)00626-8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The PML gene, involved in the t(15;17) chromosomal translocation of acute promyelocytic leukemia (APL), encodes a protein which localizes to the PML-nuclear body, a subnuclear macromolecular structure. PML controls apoptosis, cell proliferation, and senescence. Here, we review the current understanding of its role in tumor suppression.
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收藏
页码：165 / 170
页数：6
相关论文
共 29 条
[11]   Role of promyelocytic leukemia (PML) sumolation in nuclear body formation, 11S proteasome recruitment, and As2O3-induced PML or PML/retinoic acid receptor α degradation [J].
Lallemand-Breitenbach, V ;
Zhu, J ;
Puvion, F ;
Koken, M ;
Honoré, N ;
Doubeikovsky, A ;
Duprez, E ;
Pandolfi, PP ;
Puvion, E ;
Freemont, P ;
de Thé, H .
JOURNAL OF EXPERIMENTAL MEDICINE, 2001, 193 (12) :1361-1371
[12]   Recombinant PML adenovirus suppresses growth and tumorigenicity of human breast cancer cells by inducing G1 cell cycle arrest and apoptosis [J].
Le, XF ;
Vallian, S ;
Mu, ZM ;
Hung, MC ;
Chang, KS .
ONCOGENE, 1998, 16 (14) :1839-1849
[13]   Sequestration and inhibition of Daxx-mediated transcriptional repression by PML [J].
Li, H ;
Leo, C ;
Zhu, J ;
Wu, XY ;
O'Neil, J ;
Park, EJ ;
Chen, JD .
MOLECULAR AND CELLULAR BIOLOGY, 2000, 20 (05) :1784-1796
[14]   Deconstructing a disease:: RARα, its fusion partners, and their roles in the pathogenesis of acute promyelocytic leukemia [J].
Melnick, A ;
Licht, JD .
BLOOD, 1999, 93 (10) :3167-3215
[15]   In vivo analysis of the molecular genetics of acute promyelocytic leukemia [J].
Pandolfi, PP .
ONCOGENE, 2001, 20 (40) :5726-5735
[16]   PML regulates p53 acetylation and premature senescence induced by oncogenic Ras [J].
Pearson, M ;
Carbone, R ;
Sebastiani, C ;
Cioce, M ;
Fagioli, M ;
Saito, S ;
Higashimoto, Y ;
Appella, E ;
Minucci, S ;
Pandolfi, PP ;
Pelicci, PG .
NATURE, 2000, 406 (6792) :207-210
[17]   TGF-β-induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation [J].
Perlman, R ;
Schiemann, WP ;
Brooks, MW ;
Lodish, HF ;
Weinberg, RA .
NATURE CELL BIOLOGY, 2001, 3 (08) :708-714
[18]   A bcr-3 isoform of RARα-PML potentiates the development of PML-RARα-driven acute promyelocytic leukemia [J].
Pollock, JL ;
Westervelt, P ;
Kurichety, AK ;
Pelicci, PG ;
Grisolano, JL ;
Ley, TJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (26) :15103-15108
[19]   PML induces a novel caspase-independent death process [J].
Quignon, F ;
De Bels, F ;
Koken, M ;
Feunteun, J ;
Ameisen, JC ;
de Thé, H .
NATURE GENETICS, 1998, 20 (03) :259-265
[20]   The central effectors of cell death in the immune system [J].
Rathmell, JC ;
Thompson, CB .
ANNUAL REVIEW OF IMMUNOLOGY, 1999, 17 :781-828
123