P2X7 Receptors in Oligodendrocytes: A Novel Target for Neuroprotection

被引：60

作者：

Matute, Carlos ^{[1
,2
]}

机构：

[1] Univ Basque Country, CIBERNED, Dept Neurociencias, Leioa 48940, Spain

[2] Neurotek UPV EHU, Zamudio 48170, Spain

来源：

MOLECULAR NEUROBIOLOGY | 2008年 / 38卷 / 02期

关键词：

Oligodendroglia; Myelin; ATP; P2X7; Ischemia; Multiple sclerosis;

D O I：

10.1007/s12035-008-8028-x

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Intense ATP signaling through P2X7 purinergic receptors can lead to excitotoxicity, a feature which initiates neuronal demise in experimental paradigms relevant to ischemia and to traumatic injury. In addition, recent data provide evidence that oligodendrocytes also express P2X7 receptors that are activated under experimental pathological conditions involving white matter demise. Thus, this receptor subtype is a promising target for the development of new drugs to prevent white matter damage in acute and chronic diseases.

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收藏

页码：123 / 128

页数：6

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