P2X7 Receptors in Oligodendrocytes: A Novel Target for Neuroprotection

被引：60
作者：
Matute, Carlos [1 ,2 ]
机构：
[1] Univ Basque Country, CIBERNED, Dept Neurociencias, Leioa 48940, Spain
[2] Neurotek UPV EHU, Zamudio 48170, Spain
来源：
MOLECULAR NEUROBIOLOGY | 2008年 / 38卷 / 02期
关键词：
Oligodendroglia; Myelin; ATP; P2X7; Ischemia; Multiple sclerosis;
D O I：
10.1007/s12035-008-8028-x
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Intense ATP signaling through P2X7 purinergic receptors can lead to excitotoxicity, a feature which initiates neuronal demise in experimental paradigms relevant to ischemia and to traumatic injury. In addition, recent data provide evidence that oligodendrocytes also express P2X7 receptors that are activated under experimental pathological conditions involving white matter demise. Thus, this receptor subtype is a promising target for the development of new drugs to prevent white matter damage in acute and chronic diseases.
引用
收藏
页码：123 / 128
页数：6
相关论文
共 50 条
[1]   ATP regulates oligodendrocyte progenitor migration, proliferation, and differentiation:: involvement of metabotropic P2 receptors [J].
Agresti, C ;
Meomartini, ME ;
Amadio, S ;
Ambrosini, E ;
Volonté, C ;
Aloisi, F ;
Visentin, S .
BRAIN RESEARCH REVIEWS, 2005, 48 (02) :157-165
[2]   Metabotropic P2 receptor activation regulates oligodendrocyte progenitor migration and development [J].
Agresti, C ;
Meomartini, ME ;
Amadio, S ;
Ambrosini, E ;
Serafini, B ;
Franchini, L ;
Volonté, C ;
Aloisi, F ;
Visentin, S .
GLIA, 2005, 50 (02) :132-144
[3]   Emerging challenges of assigning P2X7 receptor function and immunoreactivity in neurons [J].
Anderson, CM ;
Nedergaard, M .
TRENDS IN NEUROSCIENCES, 2006, 29 (05) :257-262
[4]   Synaptic and extrasynaptic neurotransmitter receptors in glial precursors' quest for identity [J].
Belachew, S ;
Gallo, V .
GLIA, 2004, 48 (03) :185-196
[5]  
BURNSTOCK G, 1972, PHARMACOL REV, V24, P509
[6]   A His-155 to Tyr polymorphism confers gain-of-function to the human P2X7 receptor of human leukemic lymphocytes [J].
Cabrini, G ;
Falzoni, S ;
Forchap, SL ;
Pellegatti, P ;
Balboni, A ;
Agostini, P ;
Cuneo, A ;
Castoldi, G ;
Baricordi, OR ;
Di Virgilio, F .
JOURNAL OF IMMUNOLOGY, 2005, 175 (01) :82-89
[7]   Synaptic P2X7 and oxygen/glucose deprivation in organotypic hippocampal cultures [J].
Cavaliere, F ;
Amadio, S ;
Sancesario, G ;
Bernardi, G ;
Volonté, C .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2004, 24 (04) :392-398
[8]   Exacerbation of experimental autoimmune encephalomyelitis in P2X7R-/- mice:: Evidence for loss of apoptotic activity in lymphocytes [J].
Chen, LF ;
Brosnan, CF .
JOURNAL OF IMMUNOLOGY, 2006, 176 (05) :3115-3126
[9]   Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain [J].
Chessell, IP ;
Hatcher, JP ;
Bountra, C ;
Michel, AD ;
Hughes, JP ;
Green, P ;
Egerton, J ;
Murfin, M ;
Richardson, J ;
Peck, WL ;
Grahames, CBA ;
Casula, MA ;
Yiangou, Y ;
Birch, R ;
Anand, P ;
Buell, GN .
PAIN, 2005, 114 (03) :386-396
[10]   EXCITOTOXIC CELL-DEATH [J].
CHOI, DW .
JOURNAL OF NEUROBIOLOGY, 1992, 23 (09) :1261-1276
12345