Polymorphisms of the bovine WNT10B gene and their associations with growth traits

被引：2

作者：

Zhao, Jing

Zhang, Cunlei

Fang, Xingtang

Zhang, Haiyan

Liu, Xuanxuan

Li, Jingjing

Liu, Yao

Yang, Dongying ^{[2
]}

Chen, Hong ^{[1
]}

机构：

[1] Jiangsu Normal Univ, Inst Cellular & Mol Biol, Coll Life Sci, Xuzhou 221116, Jiangsu, Peoples R China

[2] Dezhou Univ, Dept Biol, Dezhou 253023, Shandong, Peoples R China

来源：

RESEARCH IN VETERINARY SCIENCE | 2012年 / 93卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Bovine; Growth traits; Mutation; WNT10B gene; RFLP; Haplotype; VARIANTS; PROMOTER; DNA;

D O I：

10.1016/j.rvsc.2012.07.008

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Wingless-type MMTV integration site family, member 10B (WNT10B) may play an important role in inhibiting differentiation of preadipocytes in vitro and impairing adipose development in vivo. In this study, based on DNA sequencing and PCR-RFLP methods, we attempted to characterize the associations between common genetic polymorphisms in WNT10B and growth traits of 435 female cattle from three breeds (Jiaxian. Qinchuan and Luxi cattle). The results indicated that g.220A>G was in the intron 1, and g.1617C>T, g.3980G>T, g.4711G>C were in the coding region. At the g.3980G>T locus, Jiaxian cattle individuals with genotype TT had greater body length than those with genotypes GG and GT (P < 0.05). At the g.220A>G locus, Qinchuan cattle individuals with genotype GG had greater growth traits than those with genotype AA and AG (P < 0.05 or P<0.01). These statistical results showed that the WNT10B gene might be a potential candidate gene for marker-assisted selection (MAS). (C) 2012 Published by Elsevier Ltd.

引用

页码：1301 / 1306

页数：6

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