A hypothetical oxidative stress regulatory role of alpha giardins in the protozoan parasite Giardia intestinalis

Giardiasis is an intestinal infection caused by the protozoan parasite Giardia intestinalis, affecting hundreds of millions of people worldwide. This microaerophilic protozoan is capable of surviving in the host intestine in the presence of both oxygen and reactive oxygen species (ROS), despite the lack of conventional ROS-scavenging enzymes. The understanding of how G. intestinalis tolerates free radicals could help to identify essential biological processes that protect themselves against oxidative stress within the human gut. This review outlines the antioxidant mechanisms that are utilized by G. intestinalis, with an emphasis on the potential novel role of alpha giardins. The comprehensive understanding of the processes involved in oxidative stress management may provide new insights into improved treatments for giardiasis, and other medically important protozoan parasitic diseases.