An unexpected reaction to methodology: an unprecedented approach to transamidation

被引：25

作者：

Rakesh, K. P. ^{[1
]}

Ramesha, A. B. ^{[2
]}

Shantharam, C. S. ^{[2
]}

Mantelingu, K. ^{[2
]}

Mallesha, N. ^{[1
]}

机构：

[1] SRI RAM CHEM, R&D Ctr, Spl 52,Ind Estate, Hebbal 16, Mysuru, India

[2] Univ Mysore, DOS Chem, Manasagangotri 06, Mysuru, India

来源：

RSC ADVANCES | 2016年 / 6卷 / 110期

关键词：

UREAS; AMINES; CARBONYLATION; CARBOXAMIDES; INHIBITORS; METAL; ACID;

D O I：

10.1039/c6ra23374k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This report describes an unprecedented protocol for the synthesis of N, N'-substituted ureas using a cross-coupling method. Mono substituted ureas were modified by an economically viable and simple method using commercially available isocyanates and sodium hydride as the reagents. In addition, the method involves no expensive metal complexes or catalysts and all reactions are carried out at room temperature. Furthermore, both symmetrical and asymmetrical ureas were successfully obtained in single step reactions with reasonable yields.

引用

页码：108315 / 108318

页数：4

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