Leveraging the cortical cholinergic system to enhance attention

被引：54
|
作者：
Demeter, Elise [1 ,2 ]
Sarter, Martin [3 ]
机构：
[1] Univ Michigan, Dept Psychiat, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Funct MRI Lab, Ann Arbor, MI 48109 USA
[3] Univ Michigan, Dept Psychol, Ann Arbor, MI 48109 USA
来源：
NEUROPHARMACOLOGY | 2013年 / 64卷
关键词：
Acetylcholine; Cognition enhancers; Attentional control; Cue detection; NICOTINIC ACETYLCHOLINE-RECEPTOR; PLACEBO-CONTROLLED TRIAL; REACTION-TIME-TASK; DEFICIT HYPERACTIVITY DISORDER; CROSSMODAL DIVIDED ATTENTION; MEDIAL PREFRONTAL CORTEX; SHORT-TERM-MEMORY; SUSTAINED ATTENTION; BASAL FOREBRAIN; ALZHEIMERS-DISEASE;
D O I：
10.1016/j.neuropharm.2012.06.060
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Attentional impairments are found in a range of neurodegenerative and neuropsychiatric disorders. However, the development of procognitive enhancers to alleviate these impairments has been hindered by a lack of comprehensive hypotheses regarding the circuitry mediating the targeted attentional functions. Here we discuss the role of the cortical cholinergic system in mediating cue detection and attentional control and propose two target mechanisms for cognition enhancers: stimulation of prefrontal alpha 4 beta 2* nicotinic acetylcholine receptors (nAChR) for the enhancement of cue detection and augmentation of tonic acetylcholine levels for the enhancement of attentional control. This article is part of a Special Issue entitled 'Cognitive Enhancers'. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：294 / 304
页数：11
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