Association of Caveolin-1 polymorphisms with colorectal cancer susceptibility in Taiwan

被引：23

作者：

Yang, Mei-Due ^{[1
]}

Tsai, Ru-Yin ^{[3
]}

Liu, Chiu-Shong ^{[2
]}

Chang, Chao-Hsiang ^{[1
]}

Wang, Hwei-Chung ^{[1
]}

Tsou, Yung-An ^{[3
]}

Wang, Chung-Hsing ^{[3
]}

Lin, Cheng-Chieh ^{[2
]}

Shyue, Song-Kun ^{[4
]}

Bau, Da-Tian ^{[3
]}

机构：

[1] China Med Univ Hosp, Dept Surg, Taichung 404, Taiwan

[2] China Med Univ Hosp, Dept Family Med, Taichung 404, Taiwan

[3] China Med Univ Hosp, Terry Fox Canc Res Lab, 2 Yuh Der Rd, Taichung 404, Taiwan

[4] Acad Sinica, Inst Biomed Sci, Taipei 115, Taiwan

来源：

WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY | 2010年 / 2卷 / 08期

关键词：

Caveolin-1; Colorectal cancer; Carcinogenesis; Polymorphism; Smoking;

D O I：

10.4251/wjgo.v2.i8.326

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

AIM: To investigate the association of Caveolin-1 (Cav-1) polymorphisms with colorectal cancer (CRC) risk in a central Taiwanese population. METHODS: Three hundred and sixty-two patients with colorectal cancer and the same number of recruited age-and gender-matched healthy controls were genotyped. And only those matches with all single nucleotide poly-morphisms data (case/control = 362/362) were selected for final analyzing. RESULTS: There were significant differences between CRC and control groups in the distributions of their genotypes (P = 1.6 x 10(-12) and 3.0 x 10(-4)) and allelic frequencies (P = 2.3 x 10(-13) and 4.0 x 10(-5)) in the Cav-1 G14713A (rs3807987) and T29107A (rs7804372) polymorphisms respectively. As for the haplotype analysis, those who had GG/AT or GG/AA at Cav-1 G14713A/ T29107A showed a 0.68-fold (95% CI: 0.48-0.98) decreased risk of CRC compared to those with GG/TT, while those of any other combinations were of increased risk. There were joint effects of Cav-1 G14713A and T29107A genotype with smoking status on individual CRC susceptibility. CONCLUSION: This is the first report providing evidence of Cav-1 being involved in CRC and it may be novel useful genomic markers for early detection of CRC. (C) 2010 Baishideng. All rights reserved.

引用

页码：326 / 331

页数：6

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