Dual role of Th17 cells in Crohn's disease

被引：5

作者：

Karczewski, Jacek ^{[1
]}

Mazur, Maciej ^{[2
]}

Karczewski, Marek ^{[1
]}

机构：

[1] Poznan Univ Med Sci, PL-61701 Poznan, Poland

[2] Solumed, Res Unit, Poznan, Poland

来源：

CENTRAL EUROPEAN JOURNAL OF IMMUNOLOGY | 2012年 / 37卷 / 03期

关键词：

IBD; Crohn's disease; Th17; IL-17; Th1/Th2/Th17; REGULATORY T-CELLS; TGF-BETA; T(H)17 CELLS; COLITIS; CYTOKINES; IL-17; DIFFERENTIATION; INTERLEUKIN-12; PATHOGENESIS; INFLAMMATION;

D O I：

10.5114/ceji.2012.30808

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Crohn's disease (CD) is a chronic relapsing, destructive inflammatory disease of the gastrointestinal (GI) tract, the cause of which remains still unknown. Accumulating evidence suggests that CD results from the imbalance between pro- and anti-inflammatory agents and the overactivity of T helper (Th)I. It seems that major cause of GI inflammation is an IL-12-driven ThI response, which results in the generation of IFN-gamma, the key inflammatory mediator Recently, however, much attention has also been given to the possible involvement of Th17 cells in the pathogenesis of CD. This mini-review is aimed to summarize the current knowledge on the dual role of Th17 cells in CD.

引用

收藏

页码：286 / 289

页数：4

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