Macrophage dynamics in diabetic wound healing

被引：35
|
作者：
Waugh, HV [1 ]
Sherratt, JA [1 ]
机构：
[1] Heriot Watt Univ, Sch Math & Comp, Edinburgh EH14 4AS, Midlothian, Scotland
来源：
BULLETIN OF MATHEMATICAL BIOLOGY | 2006年 / 68卷 / 01期
基金：
英国工程与自然科学研究理事会;
关键词：
macrophages; wound healing; diabetes;
D O I：
10.1007/s11538-005-9022-3
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Wound healing in diabetes is a complex process, characterised by a chronic inflammation phase. The exact mechanism by which this occurs is not fully understood, and whilst several treatments for healing diabetic wounds exist, very little research has been conducted towards the causes of the extended inflammation phase. We describe a mathematical model which offers a possible explanation for diabetic wound healing in terms of the distribution of macrophage phenotypes being altered in the diabetic patient compared to normal wound repair. As a consequence of this, we put forward a suggestion for treatment based on rectifying the macrophage phenotype imbalance.
引用
收藏
页码：197 / 207
页数：11
相关论文
共 50 条
  • [41] Editorial: Diabetic wound: Multifaceted mechanisms and future of diabetic wound healing
    Shao, Shiying
    Ran, Xingwu
    Li, Jibiao
    FRONTIERS IN ENDOCRINOLOGY, 2023, 13
  • [42] Bioinspired hierarchical delivery system with macrophage-like nanovesicles encapsulation for diabetic wound healing
    Che, Junyi
    Wu, Xiangyi
    Shi, Yong
    Song, Chuanhui
    Zhao, Yuanjin
    Sun, Lingyun
    CHEMICAL ENGINEERING JOURNAL, 2023, 456
  • [43] Macrophage-Specific Genetic Depletion of Cyclooxygenase-2 Improves Diabetic Wound Healing
    Melvin, William J.
    Davis, Frank
    Audu, Chris
    Barrett, Emily
    DenDekker, Aaron
    Wolf, Sonya
    Joshi, Amrita
    Gallagher, Katherine Ann
    JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS, 2020, 231 (04) : S347 - S347
  • [44] Pharmacological blockade of HDAC3 accelerates diabetic wound healing by regulating macrophage activation
    Karnam, Kalyani
    Sedmaki, Kavitha
    Sharma, Pravesh
    Mahale, Ashutosh
    Ghosh, Balaram
    Kulkarni, Onkar Prakash
    LIFE SCIENCES, 2023, 321
  • [45] Suppression of SOCS3 expression in macrophage cells: Potential application in diabetic wound healing
    Amoupour, Moein
    Milan, Peiman Brouki
    Barati, Mahmood
    Hivechi, Ahmad
    Fomeshi, Motahareh Rajabi
    Ghalesardi, Omid Kiani
    Ahmadvand, Davoud
    Osguei, Nushin Karkuki
    Samadikuchaksaraei, Ali
    INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2024, 262
  • [46] An antibacterial and antioxidant rosmarinic acid hydrogel normalizes macrophage polarization to expedite diabetic wound healing
    Xiong, Shiyu
    Ding, Xingwei
    Zhou, Ling
    Liu, Ziqian
    Jiang, Wenyan
    Ai, Fanrong
    Cai, Kaiyong
    JOURNAL OF COLLOID AND INTERFACE SCIENCE, 2025, 683 : 357 - 371
  • [47] Resveratrol accelerates wound healing by inducing M2 macrophage polarisation in diabetic mice
    Ding, Youjun
    Yang, Ping
    Li, Shiyan
    Zhang, Hao
    Ding, Xiaofeng
    Tan, Qian
    PHARMACEUTICAL BIOLOGY, 2022, 60 (01) : 2328 - 2337
  • [48] Long Noncoding RNA GAS5 Regulates Macrophage Polarization and Diabetic Wound Healing
    Hu, Junyi
    Zhang, Liping
    Liechty, Cole
    Zgheib, Carlos
    Hodges, Maggie M.
    Liechty, Kenneth W.
    Xu, Junwang
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2020, 140 (08) : 1629 - 1638
  • [49] Histone modifications and their roles in macrophage-mediated inflammation: a new target for diabetic wound healing
    Wang, Jing
    Feng, Jiawei
    Ni, Yiming
    Wang, Yuqing
    Zhang, Ting
    Cao, Yemin
    Zhou, Mingmei
    Zhao, Cheng
    FRONTIERS IN IMMUNOLOGY, 2024, 15
  • [50] Models for diabetic wound healing and healing into percutaneous devices
    Olerud, John E.
    JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, 2008, 19 (08) : 1007 - 1020
12345