Consumption of Cooked Common Beans or Saponins Could Reduce the Risk of Diabetic Complications

被引:15
作者
Calderon Guzman, David [1 ]
Juarez Olguin, Hugo [2 ,3 ]
Veloz Corona, Quetzalli [2 ]
Ortiz Herrera, Maribel [4 ]
Osnaya Brizuela, Norma [1 ]
Barragan Mejia, Gerardo [4 ]
机构
[1] Inst Nacl Pediat INP, Lab Neurosci, Mexico City, DF, Mexico
[2] INP, Lab Pharmacol, Mexico City, DF, Mexico
[3] Univ Nacl Autonoma Mexico, Fac Med, Dept Pharmacol, Mexico City, DF, Mexico
[4] INP, Lab Expt Bacteriol, Mexico City, DF, Mexico
关键词
beans; saponins; diabetes; TRITERPENOID SAPONINS; L; ANTIOXIDANT; EXTRACTS;
D O I
10.2147/DMSO.S270564
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Several risks for diseases, such as atherosclerosis, renal diseases, and diabetes, have inextricably been linked with obesity. Nowadays, this health-risk-laden disease is being managed with assorted types of drugs, some of which guarantee modest benefits. The chronic inflammatory effect of obesity has a negative effect in insulin signaling, a situation attributable to insulin resistance that culminates in high blood sugar inputs seen in diseases such as type 2 diabetes and metabolic syndrome. Food such as beans with different bioactive compounds could reduce the risk of diabetic complications. Demand for bean products is growing because of its robust contents of several health-promoting components, eg, saponins. Saponins are characterized by containing lower glucose and cholesterol levels and have been doted with antioxidant activities, as well as anti-inflammatory and anti-diabetic effects. In this writing, the attributes of saponins in providing substantial health and nutritional benefits in humans, as well as in improving and ameliorating diabetic complications, were reviewed.
引用
收藏
页码:3481 / 3486
页数:6
相关论文
共 33 条
[1]   Enzymes inhibitors from natural sources with antidiabetic activity: A review [J].
Alam, Fiaz ;
Shafique, Zainab ;
Amjad, Sayyeda Tayyeba ;
Bin Asad, Mohammad Hassham Hassan .
PHYTOTHERAPY RESEARCH, 2019, 33 (01) :41-54
[2]   A Phenolic Fraction from Catharanthus roseus L. Stems Decreases Glycemia and Stimulates Insulin Secretion [J].
Alejandra Espejel-Nava, Janet ;
Vega-Avila, Elisa ;
Alarcon-Aguilar, Francisco ;
Contreras-Ramos, Alejandra ;
Diaz-Rosas, Guadalupe ;
Trejo-Aguilar, Gloria ;
Ortega-Camarillo, Clara .
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2018, 2018
[3]   Possible role of endostatin in the antiangiogenic therapy of diabetic retinopathy [J].
Behl, Tapan ;
Kotwani, Anita .
LIFE SCIENCES, 2015, 135 :131-137
[4]   Flavonoids and saponins extracted from black bean (Phaseolus vulgaris L.) seed coats modulate lipid metabolism and biliary cholesterol secretion in C57BL/6 mice [J].
Chavez-Santoscoy, Rocio A. ;
Gutierrez-Uribe, Janet A. ;
Granados, Omar ;
Torre-Villalvazo, Ivan ;
Serna-Saldivar, Sergio O. ;
Torres, Nimbe ;
Palacios-Gonzalez, Berenice ;
Tovar, Armando R. .
BRITISH JOURNAL OF NUTRITION, 2014, 112 (06) :886-899
[5]   Current pharmacotherapeutic options for primary dyslipidemia in adults [J].
Cicero, Arrigo F. G. ;
Landolfo, Matteo ;
Ventura, Fulvio ;
Borghi, Claudio .
EXPERT OPINION ON PHARMACOTHERAPY, 2019, 20 (10) :1277-1288
[6]   Rebelling against the (Insulin) Resistance: A Review of the Proposed Insulin-Sensitizing Actions of Soybeans, Chickpeas, and Their Bioactive Compounds [J].
Clark, Jaime L. ;
Taylor, Carla G. ;
Zahradka, Peter .
NUTRIENTS, 2018, 10 (04)
[7]   Anti-diabetic activity of Holothuria thomasi saponin [J].
El Barky, Amira R. ;
Hussein, Samy A. ;
Alm-Eldeen, Abeer A. ;
Hafez, Yehia A. ;
Mohamed, Tarek M. .
BIOMEDICINE & PHARMACOTHERAPY, 2016, 84 :1472-1487
[8]   In vitro and in vivo antidiabetic potential of extracts and a furostanol saponin from Balanites aegyptiaca [J].
Ezzat, Shahira Mohammed ;
Motaal, Amira Abdel ;
El Awdan, Sally Abdel Wanees .
PHARMACEUTICAL BIOLOGY, 2017, 55 (01) :1931-1936
[9]   Activation of AMPK by Medicinal Plants and Natural Products: Its Role in Type 2 Diabetes Mellitus [J].
Francini, Flavio ;
Schinella, Guillermo R. ;
Rios, Jose-Luis .
MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2019, 19 (11) :880-901
[10]   Evaluation of the antioxidant and antiproliferative activities of extracted saponins and flavonols from germinated black beans (Phaseolus vulgaris L.) [J].
Guajardo-Flores, Daniel ;
Serna-Saldivar, Sergio O. ;
Gutierrez-Uribe, Janet A. .
FOOD CHEMISTRY, 2013, 141 (02) :1497-1503