Early electro-clinical features may contribute to diagnosis of the anti-NMDA receptor encephalitis in children

被引：71

作者：

Gitiaux, Cyril ^{[1
,2
,4
]}

Simonnet, Hina ^{[1
]}

Eisermann, Monika ^{[2
,3
]}

Leunen, Dorothee ^{[1
,3
]}

Dulac, Olivier ^{[1
,3
]}

Nabbout, Rima ^{[1
,3
,5
]}

Chevignard, Mathilde ^{[6
,7
]}

Honnorat, Jerome ^{[8
]}

Gataullina, Svetlana ^{[1
]}

Musset, Lucile ^{[9
]}

Scalais, Emmanuel ^{[10
]}

Gauthier, Agnes ^{[11
]}

Hully, Marie ^{[1
]}

Boddaert, Nathalie ^{[12
,13
]}

Kuchenbuch, Mathieu ^{[2
]}

Desguerre, Isabelle ^{[1
,4
]}

Kaminska, Anna ^{[2
,3
]}

机构：

[1] Hop Necker Enfants Malad, AP HP, Serv Neurol Pediat & Malad Metab, F-75015 Paris, France

[2] Hop Necker Enfants Malad, AP HP, Serv Explorat Fonct, Lab Neurophysiol Clin, F-75015 Paris, France

[3] Univ Paris 05, Fac Med, INSERM, U663, Paris, France

[4] Univ Paris 05, Fac Med, INSERM, U1016,CNRS8104, Paris, France

[5] Hop Necker Enfants Malad, AP HP, Ctr Reference Epilepsies Rares, F-75015 Paris, France

[6] Hop St Maurice, Serv Reeduc Pathol Neurol Acquises Enfant, St Maurice, France

[7] Hop La Pitie Salpetriere, Er 6 UPMC Paris 6, Paris, France

[8] Univ Lyon 1, Ctr Reference Malad Rare Syndromes Neurol Paraneo, Lyon Neurosci Res Ctr, Hop Neurol,INSERM,U1028,CNRS,UMR 5292, F-69365 Lyon, France

[9] CHU Pitie Salpetriere, AP HP, Dept Immunol, Paris, France

[10] Ctr Hosp Luxembourg, Serv Neurol Pediat, Luxembourg, Luxembourg

[11] CHU Nantes, Serv Pediat, Nantes, France

[12] INSERM, U1000, Paris, France

[13] Hop Necker Enfants Malad, AP HP, Serv Radiol Pediat, F-75015 Paris, France

来源：

CLINICAL NEUROPHYSIOLOGY | 2013年 / 124卷 / 12期

关键词：

Anti-NMDA receptor encephalitis; Electroencephalogram; Outcome; Child; EEG PATTERN; OSCILLATIONS; MECHANISMS; ANTIBODIES; SERIES;

D O I：

10.1016/j.clinph.2013.05.023

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective: To describe initial and follow-up electroencephalographic (EEG) characteristics in anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis. Methods: Consecutive polygraphic video-EEG recordings were analyzed in nine pediatric patients with anti-NMDAR encephalitis at the initial stage of the disease and during the intermediate period until motor recovery. EEG characteristics in waking and sleep stages as well as EEG correlates of abnormal movements are described. Results: In six of nine patients with anti-NMDAR encephalitis, the waking EEG showed preserved background activity and either focal or unilateral hemispheric slowing. During non-rapid eye movement (NREM) sleep, a decrease in the expected slow waves and unilateral or diffuse theta-alpha band rhythms were also observed in six of nine children. They all had more favorable outcome than the three children with diffuse slowing. Clinically, unilateral abnormal movements contra-lateral to hemispheric or focal slowing were also indicative of milder severity when compared to generalized abnormal movements and diffuse slowing. Conclusions: In pediatric patients presenting behavioral disorders and abnormal movements, early EEG patterns may be suggestive of anti-NMDAR encephalitis. Moreover early electro-clinical presentation contributes to outcome prediction. Significance: This case series demonstrates that early EEG patterns may be suggestive of anti-NMDAR encephalitis in pediatric patients with behavioral disorders and abnormal movements. (C) 2013 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

引用

页码：2354 / 2361

页数：8

共 30 条

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