Higher Altitude and Risk of Bronchopulmonary Dysplasia among Preterm Infants

被引:14
作者
Lee, Shoo K. [1 ]
Ye, Xiang Y. [2 ]
Singhal, Nalini [3 ]
De La Rue, Sarah [1 ]
Lodha, Abhay [3 ]
Shah, Prakesh S. [1 ]
机构
[1] Univ Toronto, Mt Sinai Hosp, Dept Pediat, Maternal Infant Care Res Ctr, Toronto, ON M5G 1X5, Canada
[2] Mt Sinai Hosp, Dept Pediat, Maternal Infant Care Res Ctr, Toronto, ON M5G 1X5, Canada
[3] Univ Calgary, Dept Pediat, Div Neonatol, Calgary, AB T2N 1N4, Canada
基金
加拿大健康研究院;
关键词
infant; premature; altitude; chronic lung disease; morbidity; BIRTH-WEIGHT; PREECLAMPSIA; PREGNANCY; SURVIVORS; COLORADO; AGE;
D O I
10.1055/s-0032-1329690
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective To assess the association between altitudes of neonatal intensive care units (NICU) and the rate of bronchopulmonary dysplasia (BPD) and BPD/death in very preterm infants. Study Design Data from infants born at <33 weeks' gestation admitted to Canadian Neonatal Network during 2008 and 2009 were analyzed. The associations between the altitude of NICU and the BPD and altitude and BPD/death were determined using logistic regression models. Results Of 7551 eligible infants, 1540 (20%) were admitted to NICUs at an altitude > 400 m, 3661 (48%) between 86 and 400 m, 2350 (31%) at <= 85 m. The incidences of BPD (21.7% versus 17.2%) and BPD/death (26.2% versus 23.0%) were significantly higher in the infants admitted to NICUs at > 400 m altitude versus those <= 400 m altitude (p < 0.01). In multivariable analyses, the adjusted odds ratio was 1.81 (95% confidence interval [CI] 1.05 to 3.12) for BPD and 1.79 (95% CI 1.12 to 2.85) for BPD/death among infants admitted to NICUs at altitude > 400 m compared with NICUs at altitude <= 400 m. For each 100-m increase in altitude, the odds increased by 8% for BPD (95% CI 4 to 13%) and 9% for BPD/death (95% CI 5 to 13%); however, the increase was mainly due to increase in BPD. Conclusion For very preterm infants, higher altitude of NICUs increased the risk of BPD.
引用
收藏
页码:601 / 606
页数:6
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