Role of granule proteases in the life and death of neutrophils

被引:31
作者
Benarafa, Charaf [1 ]
Simon, Hans-Uwe [2 ]
机构
[1] Univ Bern, Theodor Kocher Inst, Freiestr 1, CH-3012 Bern, Switzerland
[2] Univ Bern, Inst Pharmacol, Bern, Switzerland
基金
瑞士国家科学基金会; 欧盟地平线“2020”;
关键词
Neutrophils; Apoptosis; Necrosis; Cathepsin; Serine protease; Serpin; DIPEPTIDYL PEPTIDASE-I; LEUCINE METHYL-ESTER; LEUKOCYTE ELASTASE INHIBITOR; COLONY-STIMULATING FACTOR; CELL-DEATH; SERINE PROTEASES; STAPHYLOCOCCUS-AUREUS; CYTOTOXIC LYMPHOCYTES; PROTEINASE-INHIBITOR; EXTRACELLULAR TRAPS;
D O I
10.1016/j.bbrc.2016.11.086
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Neutrophils constitute a crucial component of the innate immune defenses against microbes. Produced in the bone marrow and patrolling in blood vessels, neutrophils are recruited to injured tissues and are immediately active to contain pathogen invasion. Neutrophils undergo programmed cell death by multiple, context-specific pathways, which have consequences on immunopathology and disease outcome. Studies in the last decade indicate additional functions for neutrophils - or a subset of neutrophils in modulating adaptive responses and tumor progression. Neutrophil granules contain abundant amounts of various proteases, which are directly implicated in protective and pathogenic functions of neutrophils. It now emerges that neutral serine proteases such as cathepsin G and proteinase-3 also contribute to the neutrophil life cycle, but do so via different pathways than that of the aspartate protease cathepsin D and that of mutants of the serine protease elastase. The aim of this review is to appraise the present knowledge of the function of neutrophil granule proteases and their inhibitors in neutrophil cell death, and to integrate these findings in the current understandings of neutrophil life cycle and programmed cell death pathways. (C) 2016 Elsevier Inc. All rights reserved.
引用
收藏
页码:473 / 481
页数:9
相关论文
共 122 条
[1]  
Adkison AM, 2002, J CLIN INVEST, V109, P363, DOI 10.1172/JCI200213462
[2]   Lysosomal cell death at a glance [J].
Aits, Sonja ;
Jaattela, Marja .
JOURNAL OF CELL SCIENCE, 2013, 126 (09) :1905-1912
[3]   Clinical spectrum, pathophysiology and treatment of the Wiskott-Aldrich syndrome [J].
Albert, Michael H. ;
Notarangelo, Luigi D. ;
Ochs, Hans D. .
CURRENT OPINION IN HEMATOLOGY, 2011, 18 (01) :42-48
[4]   Calpain-1 regulates Bax and subsequent Smac-dependent caspase-3 activation in neutrophil apoptosis [J].
Altznauer, F ;
Conus, S ;
Cavalli, A ;
Folkers, G ;
Simon, HU .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (07) :5947-5957
[5]   Inflammation-associated cell cycle-independent block of apoptosis by survivin in terminally differentiated neutrophils [J].
Altznauer, F ;
Martinelli, S ;
Yousefi, S ;
Thürig, C ;
Schmid, I ;
Conway, EM ;
Schöni, MH ;
Vogt, P ;
Mueller, C ;
Fey, MF ;
Zangemeister-Wittke, U ;
Simon, HU .
JOURNAL OF EXPERIMENTAL MEDICINE, 2004, 199 (10) :1343-1354
[6]   Induction of Bim limits cytokine-mediated prolonged survival of neutrophils [J].
Andina, N. ;
Conus, S. ;
Schneider, E. M. ;
Fey, M. F. ;
Simon, H. U. .
CELL DEATH AND DIFFERENTIATION, 2009, 16 (09) :1248-1255
[7]   SerpinB1 is critical for neutrophil survival through cell-autonomous inhibition of cathepsin G [J].
Baumann, Mathias ;
Pham, Christine T. N. ;
Benarafa, Charaf .
BLOOD, 2013, 121 (19) :3900-3907
[8]   Mice lacking neutrophil elastase reveal impaired host defense against gram negative bacterial sepsis [J].
Belaaouaj, A ;
McCarthy, R ;
Baumann, M ;
Gao, ZM ;
Ley, TJ ;
Abraham, SN ;
Shapiro, SD .
NATURE MEDICINE, 1998, 4 (05) :615-618
[9]   Characterization of four murine homologs of the human ov-serpin monocyte neutrophil elastase inhibitor MNEI (SERPINB1) [J].
Benarafa, C ;
Cooley, J ;
Zeng, WL ;
Bird, PI ;
Remold-O'Donnell, E .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (44) :42028-42033
[10]   The neutrophil serine protease inhibitor serpinb1 preserves lung defense functions in Pseudomonas aeruginosa infection [J].
Benarafa, Charaf ;
Priebe, Gregory P. ;
Remold-O'Donnell, Eileen .
JOURNAL OF EXPERIMENTAL MEDICINE, 2007, 204 (08) :1901-1909