Neutrophils constitute a crucial component of the innate immune defenses against microbes. Produced in the bone marrow and patrolling in blood vessels, neutrophils are recruited to injured tissues and are immediately active to contain pathogen invasion. Neutrophils undergo programmed cell death by multiple, context-specific pathways, which have consequences on immunopathology and disease outcome. Studies in the last decade indicate additional functions for neutrophils - or a subset of neutrophils in modulating adaptive responses and tumor progression. Neutrophil granules contain abundant amounts of various proteases, which are directly implicated in protective and pathogenic functions of neutrophils. It now emerges that neutral serine proteases such as cathepsin G and proteinase-3 also contribute to the neutrophil life cycle, but do so via different pathways than that of the aspartate protease cathepsin D and that of mutants of the serine protease elastase. The aim of this review is to appraise the present knowledge of the function of neutrophil granule proteases and their inhibitors in neutrophil cell death, and to integrate these findings in the current understandings of neutrophil life cycle and programmed cell death pathways. (C) 2016 Elsevier Inc. All rights reserved.
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Adkison AM, 2002, J CLIN INVEST, V109, P363, DOI 10.1172/JCI200213462
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Danish Canc Soc, Res Ctr, Cell Death & Metab Unit, DK-2100 Copenhagen, DenmarkDanish Canc Soc, Res Ctr, Cell Death & Metab Unit, DK-2100 Copenhagen, Denmark
Aits, Sonja
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Jaattela, Marja
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Danish Canc Soc, Res Ctr, Cell Death & Metab Unit, DK-2100 Copenhagen, DenmarkDanish Canc Soc, Res Ctr, Cell Death & Metab Unit, DK-2100 Copenhagen, Denmark
机构:Washington Univ, Sch Med, Barnes Jewish Hosp, Dept Cell Biol, St Louis, MO 63110 USA
Belaaouaj, A
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McCarthy, R
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机构:Washington Univ, Sch Med, Barnes Jewish Hosp, Dept Cell Biol, St Louis, MO 63110 USA
McCarthy, R
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Baumann, M
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Baumann, M
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Gao, ZM
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Gao, ZM
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Ley, TJ
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Ley, TJ
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Abraham, SN
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机构:Washington Univ, Sch Med, Barnes Jewish Hosp, Dept Cell Biol, St Louis, MO 63110 USA
Abraham, SN
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Shapiro, SD
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Washington Univ, Sch Med, Barnes Jewish Hosp, Dept Cell Biol, St Louis, MO 63110 USAWashington Univ, Sch Med, Barnes Jewish Hosp, Dept Cell Biol, St Louis, MO 63110 USA
机构:
Danish Canc Soc, Res Ctr, Cell Death & Metab Unit, DK-2100 Copenhagen, DenmarkDanish Canc Soc, Res Ctr, Cell Death & Metab Unit, DK-2100 Copenhagen, Denmark
Aits, Sonja
;
Jaattela, Marja
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Danish Canc Soc, Res Ctr, Cell Death & Metab Unit, DK-2100 Copenhagen, DenmarkDanish Canc Soc, Res Ctr, Cell Death & Metab Unit, DK-2100 Copenhagen, Denmark
机构:Washington Univ, Sch Med, Barnes Jewish Hosp, Dept Cell Biol, St Louis, MO 63110 USA
Belaaouaj, A
;
McCarthy, R
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机构:Washington Univ, Sch Med, Barnes Jewish Hosp, Dept Cell Biol, St Louis, MO 63110 USA
McCarthy, R
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Baumann, M
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机构:Washington Univ, Sch Med, Barnes Jewish Hosp, Dept Cell Biol, St Louis, MO 63110 USA
Baumann, M
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Gao, ZM
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机构:Washington Univ, Sch Med, Barnes Jewish Hosp, Dept Cell Biol, St Louis, MO 63110 USA
Gao, ZM
;
Ley, TJ
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机构:Washington Univ, Sch Med, Barnes Jewish Hosp, Dept Cell Biol, St Louis, MO 63110 USA
Ley, TJ
;
Abraham, SN
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机构:Washington Univ, Sch Med, Barnes Jewish Hosp, Dept Cell Biol, St Louis, MO 63110 USA
Abraham, SN
;
Shapiro, SD
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Washington Univ, Sch Med, Barnes Jewish Hosp, Dept Cell Biol, St Louis, MO 63110 USAWashington Univ, Sch Med, Barnes Jewish Hosp, Dept Cell Biol, St Louis, MO 63110 USA