Heterocyclic aminoparthenolide derivatives modulate G2-M cell cycle progression during Xenopus oocyte maturation

被引：13
|
作者：
Janganati, Venumadhav [1 ]
Penthala, Narsimha Reddy [1 ]
Cragle, Chad E. [2 ]
MacNicol, Angus M. [2 ]
Crooks, Peter A. [1 ]
机构：
[1] Univ Arkansas Med Sci, Dept Pharmaceut Sci, Coll Pharm, Little Rock, AR 72205 USA
[2] Univ Arkansas Med Sci, Dept Neurobiol & Dev Sci, Little Rock, AR 72205 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2014年 / 24卷 / 08期
关键词：
Parthenolide; Oocyte maturation; Progesterone; Michael addition; Heterocyclic amines; MESSENGER-RNA TRANSLATION; FACTOR-KAPPA-B; SESQUITERPENE LACTONE; INHIBIT; MEIOSIS; REVEALS; PATHWAY; SCREEN; KINASE; PARTHENOLIDE;
D O I：
10.1016/j.bmcl.2014.02.067
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Aminoparthenolide derivatives have been prepared by reaction of parthenolide with various heterocyclic amines to afford corresponding Michael addition products. These novel compounds were evaluated for their modulatory effects on Xenopus oocyte maturation. Two compounds, 6e and 6f, were identified that promote G2-M cell cycle progression. (c) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1963 / 1967
页数：5
相关论文
共 50 条
  • [21] Ciprofloxacin mediated cell growth inhibition, S/G2-M cell cycle arrest, and apoptosis in a human transitional cell carcinoma of the bladder cell line
    Aranha, O
    Wood, DP
    Sarkar, FH
    CLINICAL CANCER RESEARCH, 2000, 6 (03) : 891 - 900
  • [22] Antiproliferative effect of β-elemene in chemoresistant ovarian carcinoma cells is mediated through arrest of the cell cycle at the G2-M phase
    Li, X
    Wang, G
    Zhao, J
    Ding, H
    Cunningham, C
    Chen, F
    Flynn, DC
    Reed, E
    Li, QQ
    CELLULAR AND MOLECULAR LIFE SCIENCES, 2005, 62 (7-8) : 894 - 904
  • [23] PD98059 prevents establishment of the spindle assembly checkpoint and inhibits the G2-M transition in meiotic but not mitotic cell cycles in Xenopus
    Cross, DAE
    Smythe, C
    EXPERIMENTAL CELL RESEARCH, 1998, 241 (01) : 12 - 22
  • [24] CASEIN KINASE-II IS REQUIRED FOR CELL-CYCLE PROGRESSION DURING G(1) AND G(2)/M IN SACCHAROMYCES-CEREVISIAE
    HANNA, DE
    RETHINASWAMY, A
    GLOVER, CVC
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (43) : 25905 - 25914
  • [25] DRG2 binds to Wee1 for regulating cell cycle progression during G2/M phase
    Jang, S.
    Park, N.
    Kim, S.
    Park, J.
    Han, I.
    MOLECULAR BIOLOGY OF THE CELL, 2014, 25
  • [26] High-dose zearalenone exposure disturbs G2/M transition during mouse oocyte maturation
    Ji, Yi-Ming
    Zhang, Kun-Huan
    Pan, Zhen-Nan
    Ju, Jia-Qian
    Zhang, Hao-Lin
    Liu, Jing-Cai
    Wang, Yue
    Sun, Shao-Chen
    REPRODUCTIVE TOXICOLOGY, 2022, 110 : 172 - 179
  • [27] Propylparaben exposure impairs G2/M and metaphase-anaphase transition during mouse oocyte maturation
    Pan, Zhen-Nan
    Zhuang, Li-Li
    Zhao, Hui-Shan
    Yin, Shu-Yuan
    Chu, Min
    Liu, Xiao-Yan
    Bao, Hong-Chu
    ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2024, 283
  • [28] Cell cycle trails in Salamanca - Workshop on G2/M progression and associated checkpoints
    Pines, J
    EMBO REPORTS, 2002, 3 (01) : 17 - 21
  • [29] NQO1 regulates cell cycle progression at the G2/M phase
    Oh, Eun-Taex
    Kim, Ha Gyeong
    Kim, Chul Hoon
    Lee, Jeonghun
    Kim, Chulhee
    Lee, Jae-Seon
    Cho, Yunmi
    Park, Heon Joo
    THERANOSTICS, 2023, 13 (02): : 873 - 895
  • [30] Phosphorylation of p62 by protein kinase CKII during G2/M phases of cell cycle progression
    Kwon, JH
    Shin, JK
    MOLECULAR BIOLOGY OF THE CELL, 2001, 12 : 407A - 407A
12345