Heterocyclic aminoparthenolide derivatives modulate G2-M cell cycle progression during Xenopus oocyte maturation

被引：13
|
作者：
Janganati, Venumadhav [1 ]
Penthala, Narsimha Reddy [1 ]
Cragle, Chad E. [2 ]
MacNicol, Angus M. [2 ]
Crooks, Peter A. [1 ]
机构：
[1] Univ Arkansas Med Sci, Dept Pharmaceut Sci, Coll Pharm, Little Rock, AR 72205 USA
[2] Univ Arkansas Med Sci, Dept Neurobiol & Dev Sci, Little Rock, AR 72205 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2014年 / 24卷 / 08期
关键词：
Parthenolide; Oocyte maturation; Progesterone; Michael addition; Heterocyclic amines; MESSENGER-RNA TRANSLATION; FACTOR-KAPPA-B; SESQUITERPENE LACTONE; INHIBIT; MEIOSIS; REVEALS; PATHWAY; SCREEN; KINASE; PARTHENOLIDE;
D O I：
10.1016/j.bmcl.2014.02.067
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Aminoparthenolide derivatives have been prepared by reaction of parthenolide with various heterocyclic amines to afford corresponding Michael addition products. These novel compounds were evaluated for their modulatory effects on Xenopus oocyte maturation. Two compounds, 6e and 6f, were identified that promote G2-M cell cycle progression. (c) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1963 / 1967
页数：5
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