The cytotoxicity of 8-O-4′ neolignans from the seeds of Crataegus pinnatifida

被引：83

作者：

Huang, Xiao-Xiao ^{[1
,4
]}

Zhou, Chen-Chen ^{[1
,4
]}

Li, Ling-Zhi ^{[1
,4
]}

Li, Fei-Fei ^{[1
,4
]}

Lou, Li-Li ^{[7
]}

Li, Dian-Ming ^{[8
]}

Ikejima, Takshi ^{[5
]}

Peng, Ying ^{[6
]}

Song, Shao-Jiang ^{[1
,2
,3
,4
]}

机构：

[1] Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Shenyang, Peoples R China

[2] Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China

[3] Peking Union Med Coll, Beijing 100050, Peoples R China

[4] Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang, Peoples R China

[5] Shenyang Pharmaceut Univ, Minist Educ, China Japan Res Inst Med Pharmaceut Sci, Shenyang, Peoples R China

[6] Shenyang Pharmaceut Univ, Sch Pharm, Shenyang, Peoples R China

[7] Harbin Pharmaceut Grp Co Ltd, Gen Pharmaceut Factory, Harbin 150046, Peoples R China

[8] Harbin Pharmaceut Grp Co Ltd, Chinese Med Factory 2, Harbin 150078, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2013年 / 23卷 / 20期

关键词：

Crataegus pinnatifida; 8-O-4; Neolignans; Cytotoxicities; IN-VITRO; LIGNANS; ANTITUMOR; RHIZOMES; LEAVES; STEM;

D O I：

10.1016/j.bmcl.2013.08.045

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Nine new 8-O-4' neolignans, named pinnatifidanin B I-IX (1-9), together with 9 known analogs (10-18) were isolated from the seeds of Crataegus pinnatifida. The structures of 1-18 were determined by spectroscopic methods, including 1D, 2D NMR, CD and HRESIMS analysis. Compounds 8-11, 17 and 18 displayed potent cytotoxic activities against human cancer cell lines, and most interestingly, none of the 6 compounds displayed inhibitory activity against human lung cell line (Mrc5). The 6 cytotoxic compounds are considered to be potential as antitumor agents, which could significantly inhibit the cancer cell growth in a dose-dependent manner and are probably safer than positive control drug. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：5599 / 5604

页数：6

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