Addition of ethynylferrocene to transition-metal complexes containing a chelating 1,2-dicarba-closo-dodecaborane-1,2-dichalcogenolate ligand-in vitro cooperativity of a ruthenium compound on cellular uptake of an anticancer drug

被引：50
作者：
Wu, De-Hong [2 ]
Wu, Chun-Hui [1 ]
Li, Yi-Zhi [2 ]
Guo, Da-Dong [1 ]
Wang, Xue-Mei [1 ]
Yan, Hong [2 ]
机构：
[1] Southeast Univ, State Key Lab Bioelect, Chien Shiung Wu Lab, Nanjing 210096, Jiangsu, Peoples R China
[2] Nanjing Univ, Sch Chem & Chem Engn, State Key Lab Coordinat Chem, Nanjing 210093, Jiangsu, Peoples R China
来源：
DALTON TRANSACTIONS | 2009年 / 02期
基金：
中国国家自然科学基金;
关键词：
CP-ASTERISK-RH; HALF-SANDWICH COMPLEXES; B-H ACTIVATION; METHYL ACETYLENE CARBOXYLATES; ESTROGEN-RECEPTOR MODULATORS; MULTIDRUG-RESISTANCE; MULTIFUNCTIONAL MEDICINES; HALFSANDWICH COMPLEXES; OXIDATIVE-ADDITION; ARENE COMPLEXES;
D O I：
10.1039/b810831e
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The addition reactions of the 16e half-sandwich complexes (p-cymene) M(S2C2B10H10) (1S, M = Ru; 2S, M = Os) and Cp*Ir(E2C2B10H10) (3S, E = S; 3Se, E = Se) with ethynylferrocene lead selectively to the 18e complexes (p-cymene) Ru(S2C2B10H9)(H(2)CCFc) (Fc = ferrocenyl) (4S), (p-cymene) Os(S2C2B10H9)(H(2)CCFc) (5S), Cp*Ir(S2C2B10H9)(H(2)CCFc) (6S) and Cp*Ir(Se2C2B10H9)(H(2)CCFc) (6Se), in which the alkyne is regio-and stereoselectively inserted into one of the M-E bonds that may further lead to metal-induced B-H activation, hydrogen atom transfer from the carborane via the metal center to the inserted alkyne, and the generation of a M-B bond. In all complexes the S-eta(2)-(Fc) C-C and C-B(M) moieties occupy a cisoid position. The four new complexes are characterized by IR, MS, NMR spectroscopy and microanalysis, and the X-ray structural analysis of 4S is performed. 4S was observed to promote the uptake of anticancer drug daunorubicin in drug-resistant leukemia K562 cells.
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页码：285 / 290
页数：6
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