The therapeutic potential of neural stem cells

被引：580
作者：
Martino, G
Pluchino, S
机构：
[1] Ist Sci San Raffaele, DIBIT, Neuroimmunol Unit, I-20132 Milan, Italy
[2] Ist Sci San Raffaele, Dept Neurol & Neurophysiol, I-20132 Milan, Italy
来源：
NATURE REVIEWS NEUROSCIENCE | 2006年 / 7卷 / 05期
关键词：
D O I：
10.1038/nrn1908
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Recent evidence shows that transplantation of neural stem/precursor cells may protect the central nervous system from inflammatory damage through a 'bystander' mechanism that is alternative to cell replacement. This novel mechanism, which might improve the success of transplantation procedures, is exerted by undifferentiated neural stem cells, the functional characteristics of which are regulated by important stem cell regulators released by CNS-resident and blood-borne inflammatory cells. Here, we discuss this alternative bystander mechanism in the context of the atypical ectopic perivascular niche. We propose that it is the most challenging example of reciprocal therapeutic crosstalk between the inflamed CNS and systemically transplanted neural stem cells.
引用
收藏
页码：395 / 406
页数：12
相关论文
共 175 条
[1]   Neural stem cells display extensive tropism for pathology in adult brain: Evidence from intracranial gliomas [J].
Aboody, KS ;
Brown, A ;
Rainov, NG ;
Bower, KA ;
Liu, SX ;
Yang, W ;
Small, JE ;
Herrlinger, U ;
Ourednik, V ;
Black, PM ;
Breakefield, XO ;
Snyder, EY .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (23) :12846-12851
[2]   PERIVENTRICULAR LESIONS IN MULTIPLE-SCLEROSIS - THEIR PERIVENOUS ORIGIN AND RELATIONSHIP TO ANTIGRANULOCYTES EPENDYMITIS [J].
ADAMS, CWM ;
ABDULLA, YH ;
TORRES, EM ;
POSTON, RN .
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 1987, 13 (02) :141-152
[3]  
AHMED S, 1995, J NEUROSCI, V15, P5765
[4]   Transplantation of clonal neural precursor cells derived from adult human brain establishes functional peripheral myelin in the rat spinal cord [J].
Akiyama, Y ;
Honmou, O ;
Kato, T ;
Uede, T ;
Hashi, K ;
Kocsis, JD .
EXPERIMENTAL NEUROLOGY, 2001, 167 (01) :27-39
[5]   Astrocytes produce CNTF during the remyelination phase of viral-induced spinal cord demyelination to stimulate FGF-2 production [J].
Albrecht, PJ ;
Murtie, JC ;
Ness, JK ;
Redwine, JM ;
Enterline, JR ;
Armstrong, RC ;
Levison, SW .
NEUROBIOLOGY OF DISEASE, 2003, 13 (02) :89-101
[6]   Regulation of T-cell responses by CNS antigen-presenting cells: different roles for microglia and astrocytes [J].
Aloisi, F ;
Ria, F ;
Adorini, L .
IMMUNOLOGY TODAY, 2000, 21 (03) :141-147
[7]   AUTORADIOGRAPHIC AND HISTOLOGICAL STUDIES OF POSTNATAL NEUROGENESIS .3. DATING TIME OF PRODUCTION AND ONSET OF DIFFERENTIATION OF CEREBELLAR MICRONEURONS IN RATS [J].
ALTMAN, J .
JOURNAL OF COMPARATIVE NEUROLOGY, 1969, 136 (03) :269-&
[8]   AUTORADIOGRAPHIC AND HISTOLOGICAL EVIDENCE OF POSTNATAL HIPPOCAMPAL NEUROGENESIS IN RATS [J].
ALTMAN, J ;
DAS, GD .
JOURNAL OF COMPARATIVE NEUROLOGY, 1965, 124 (03) :319-&
[9]   For the long run: Maintaining germinal niches in the adult brain [J].
Alvarez-Buylla, A ;
Lim, DA .
NEURON, 2004, 41 (05) :683-686
[10]  
Arlotta P, 2003, ANN NY ACAD SCI, V991, P229
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