Formulation optimization and evaluation of jackfruit seed starch-alginate mucoadhesive beads of metformin HCl

被引：56

作者：

Nayak, Amit Kumar ^{[1
]}

Pal, Dilipkumar ^{[2
]}

机构：

[1] Seemanta Inst Pharmaceut Sci, Dept Pharmaceut, Mayurbhanj 757086, Odisha, India

[2] Guru Ghasidas Vishwavidyalaya, Dept Pharmaceut Sci, Bilashpur 495009, CG, India

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2013年 / 59卷

关键词：

Jackfruit seed starch; Mucoadhesion; Drug release; Metformin HCl; Factorial design; IN-VITRO EVALUATION; CONTROLLED-RELEASE; SODIUM ALGINATE; GLICLAZIDE; DESIGN; MUCILAGE; MICROCAPSULES; MICROSPHERES; MICROBEADS; CHITOSAN;

D O I：

10.1016/j.ijbiomac.2013.04.062

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The present study deals with the formulation optimization of jackfruit (Artocarpus heterophyllus Lam., family: Moraceae) seed starch (JFSS)-alginate mucoadhesive beads containing metformin HCl through ionotropic gelation using 3(2) factorial design. The effect of sodium alginate to JFSS ratio and CaCl2 concentration on the drug encapsulation efficiency (DEE, %), and cumulative drug release at 10 h (R-10 (h) %) was optimized. The optimized beads containing metformin HCl showed DEE of 97.48 +/- 3.92%, R-10 (h) of 65.70 +/- 2.22%, and mean diameter of 1.16 +/- 0.11 mm. The in vitro drug release from these beads was followed controlled-release (zero-order) pattern with super case-II transport mechanism. The beads were also characterized by SEM and FTIR. The swelling and degradation of these beads were influenced by pH of the test medium. The optimized beads also exhibited good mucoadhesivity and significant hypoglycemic effect in alloxan-induced diabetic rats over prolonged period after oral administration. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：264 / 272

页数：9