Theta-burst transcranial magnetic stimulation induced functional connectivity changes between dorsolateral prefrontal cortex and default-mode-network

被引：14

作者：

Shang, Yuanqi ^{[1
]}

Chang, Da ^{[1
]}

Zhang, Jian ^{[1
]}

Peng, Wei ^{[1
]}

Song, Donghui ^{[1
]}

Gao, Xin ^{[1
]}

Wang, Ze ^{[2
]}

机构：

[1] Hangzhou Normal Univ, Inst Psychol Sci, Ctr Cognit & Brain Disorders, Hangzhou, Peoples R China

[2] Univ Maryland, Sch Med, Dept Diagnost Radiol & Nucl Med, 670 St,Room 1173, Baltimore, MD 21201 USA

来源：

BRAIN IMAGING AND BEHAVIOR | 2020年 / 14卷 / 05期

基金：

中国国家自然科学基金;

关键词：

Transcranial magnetic stimulation (TMS); Functional connectivity; Dorsolateral prefrontal cortex; Default mode network; Cerebral blood flow (CBF); RESTING-STATE NETWORKS; PRIMARY MOTOR CORTEX; CEREBRAL-BLOOD-FLOW; BRAIN-STIMULATION; RTMS; FLUCTUATIONS; EXCITABILITY; INVOLVEMENT; IMPACT; FMRI;

D O I：

10.1007/s11682-019-00139-y

中图分类号：

R445 [影像诊断学];

学科分类号：

100207 ;

摘要：

Functional connectivity (FC) is fundamental to brain function and has been implicated in many neuropsychological and neuropsychiatric disorders. It is then of great scientific and clinical interest to find a non-invasive approach to modulate FC. Transcranial magnetic stimulation (TMS) is a non-invasive neuromodulational tool that can affect the target region and remote brain areas. While the distributed effects of TMS are postulated to be through either structural or functional connectivity, an understudied but of great scientific interest question is whether TMS can change the FC between these regions. The purpose of this study was to address this question in normal healthy brain using TMS with continuous theta burst stimulation (cTBS) pulses, which are known to have long-lasting inhibition function. FC was calculated from resting state fMRI before and after real and control (SHAM) stimulation. Compared to SHAM, the repetitive TMS (rTMS) reduces FC between the cTBS target: the left dorsolateral prefrontal cortex (lDLPFC) and brain regions within the default mode network (DMN), proving the effects of rTMS on FC. The reduction of FC might be the results of the inhibitory effects of cTBS rTMS.

引用

页码：1955 / 1963

页数：9

共 59 条

[1]

BARKER AT, 1985, LANCET, V1, P1106

[2] FUNCTIONAL CONNECTIVITY IN THE MOTOR CORTEX OF RESTING HUMAN BRAIN USING ECHO-PLANAR MRI [J].

BISWAL, B ;

YETKIN, FZ ;

HAUGHTON, VM ;

HYDE, JS .

MAGNETIC RESONANCE IN MEDICINE, 1995, 34 (04) :537-541

[3]

Biswal BB, 1997, NMR BIOMED, V10, P165, DOI 10.1002/(SICI)1099-1492(199706/08)10:4/5<165::AID-NBM454>3.0.CO

[4]

2-7

[5] Transcranial Magnetic Stimulation: Disrupting Neural Activity to Alter and Assess Brain Function [J].

Bolognini, Nadia ;

Ro, Tony .

JOURNAL OF NEUROSCIENCE, 2010, 30 (29) :9647-9650

[6] Relation between the electroforming voltage in alkali halide-polymer diodes and the bandgap of the alkali halide [J].

Bory, Benjamin F. ;

Wang, Jingxin ;

Gomes, Henrique L. ;

Janssen, Rene A. J. ;

De Leeuw, Dago M. ;

Meskers, Stefan C. J. .

APPLIED PHYSICS LETTERS, 2014, 105 (23)

[7]

Chan R. W., 2017, P NATL ACAD SCI, P201703309

[8] Causal interactions between fronto-parietal central executive and default-mode networks in humans [J].

Chen, Ashley C. ;

Oathes, Desmond J. ;

Chang, Catie ;

Bradley, Travis ;

Zhou, Zheng-Wei ;

Williams, Leanne M. ;

Glover, Gary H. ;

Deisseroth, Karl ;

Etkin, Amit .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (49) :19944-19949

[9] Hierarchical clustering to measure connectivity in fMRI resting-state data [J].

Cordes, D ;

Haughton, V ;

Carew, JD ;

Arfanakis, K ;

Maravilla, K .

MAGNETIC RESONANCE IMAGING, 2002, 20 (04) :305-317

[10]

Cordes D, 2000, AM J NEURORADIOL, V21, P1636

← 1 2 3 4 5 6 →