The Role of Chondroitin Sulfate Proteoglycans in Nervous System Development

被引：48

作者：

Mencio, Caitlin P. ^{[1
]}

Hussein, Rowan K. ^{[1
]}

Yu, Panpan ^{[2
]}

Geller, Herbert M. ^{[1
]}

机构：

[1] NHLBI, Dev Neurobiol Lab, Cell & Dev Biol Ctr, Bldg 10, Bethesda, MD 20892 USA

[2] Jinan Univ, Guangdong Hongkong Macau Inst CNS Regenerat, Minist Educ Joint Int Res Lab CNS Regenerat, Guangzhou, Peoples R China

来源：

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY | 2021年 / 69卷 / 01期

关键词：

axon guidance; extracellular matrix; glycosaminoglycans; neural migration; neurogenesis; proteoglycans; synapse formation; PROTEIN-TYROSINE-PHOSPHATASE; PDGF ALPHA-RECEPTOR; NEURAL STEM-CELLS; EXTRACELLULAR-MATRIX MOLECULES; O2A PROGENITOR CELLS; PERINEURONAL NETS; MONOCLONAL-ANTIBODY; NG2; PROTEOGLYCAN; NEURITE OUTGROWTH; ZETA/RPTP-BETA;

D O I：

10.1369/0022155420959147

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The orderly development of the nervous system is characterized by phases of cell proliferation and differentiation, neural migration, axonal outgrowth and synapse formation, and stabilization. Each of these processes is a result of the modulation of genetic programs by extracellular cues. In particular, chondroitin sulfate proteoglycans (CSPGs) have been found to be involved in almost every aspect of this well-orchestrated yet delicate process. The evidence of their involvement is complex, often contradictory, and lacking in mechanistic clarity; however, it remains obvious that CSPGs are key cogs in building a functional brain. This review focuses on current knowledge of the role of CSPGs in each of the major stages of neural development with emphasis on areas requiring further investigation:

引用

页码：61 / 80

页数：20

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