Isoindole Derivatives: Propitious Anticancer Structural Motifs

被引：55
作者：
Bhatia, Richa Kaur [1 ]
机构：
[1] Chandigarh Coll Pharm, Dept Pharmaceut Chem, Landran 140307, Mohali, India
来源：
CURRENT TOPICS IN MEDICINAL CHEMISTRY | 2017年 / 17卷 / 02期
关键词：
Anti-cancer agents; Isoindole; Isoindoline; Isoindolinone; Phthalimide; Chemotherapy; POTENTIAL ANTITUMOR AGENTS; CULTURED CELL-LINES; SYNTHASE KINASE 3; ANTIPROLIFERATIVE ACTIVITY; BIOLOGICAL EVALUATION; CYTOSTATIC AGENTS; BATRACYLIN; ANALOGS; INHIBITORS; ACID;
D O I：
10.2174/1568026616666160530154100
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Isoindole derivatives constitute an important class of biologically active heterocyclic compounds and continue to attract considerable attention due to their diverse pharmacological profile such as, antimicrobial, anthelmintic, insecticidal, cyclooxygenase isoenzyme (COX-2) and thrombin Inhibition with special emphasis on anticancer activity. This review highlights anticancer properties of isoindole derivatives and its related structures and hoping that it would further help in generation of new concepts towards rational design and development of more potent and less toxic anticancer agents.
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页码：189 / 207
页数：19
相关论文
共 153 条
[1]  
4Sc Ag, 2009, [No title captured], Patent No. [WO2009112550, 2009112550, WO 2009112550 A1]
[2]  
Abdel-Rahman A. A. H., 2013, Der Pharma Chemica, V5, P358
[3]  
Abe Y., 2010, Patent No. [WO 2010061907 A1, 2010061907]
[4]  
AHMED S, 2006, Patent No. 2006017443
[5]  
Al- Obaid A. M., 1999, SCI PHARM, V67, P129
[6]  
Aliabadi A., 2012, J REP PHARM SCI, V1, P23
[7]   Phthalimide analogs as probable 15-lipoxygenase-1 inhibitors: synthesis, biological evaluation and docking studies [J].
Aliabadi, Alireza ;
Mohammadi-Farani, Ahmad ;
Hosseinzadeh, Zeinab ;
Nadri, Hamid ;
Moradi, Alireza ;
Ahmadi, Farahnaz .
DARU-JOURNAL OF PHARMACEUTICAL SCIENCES, 2015, 23
[8]   Chlorizidine, a Cytotoxic 5H-Pyrrolo[2,1-a]isoindol-5-one-Containing Alkaloid from a Marine Streptomyces sp. [J].
Alvarez-Mico, Xavier ;
Jensen, Paul R. ;
Fenical, William ;
Hughes, Chambers C. .
ORGANIC LETTERS, 2013, 15 (05) :988-991
[9]  
Andy Parthan, 1994, ACTA ONCOL, V33, P953
[10]  
[Anonymous], 2014, Nerviano Medical Sciences S, Patent No. [WO 2014064149 A1, 2014064149, WO 2014064149]
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