Inhibition of placental ornithine decarboxylase by DL-α-difluoro-methyl ornithine causes fetal growth restriction in rat

被引：24

作者：

Ishida, M ^{[1
]}

Hiramatsu, Y ^{[1
]}

Masuyama, H ^{[1
]}

Mizutani, Y ^{[1
]}

Kudo, T ^{[1
]}

机构：

[1] Okayama Univ, Sch Med, Dept Obstet & Gynecol, Okayama 7008558, Japan

来源：

LIFE SCIENCES | 2002年 / 70卷 / 12期

关键词：

ornithine decarboxylase; DL-alpha-difluoromethyl ornithine; intrauterine growth restriction; rat;

D O I：

10.1016/S0024-3205(01)01510-7

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The roles of polyamines in intrauterine growth restriction (IUGR) is studied. The DL-alpha-difluoromethyl ornithine (DFMO), an irreversible inhibitor of ornithine decarboxylase (ODC) which is a rate limiting enzyme of polyamine synthesis was administrated to pregnant rats so that we obtained rat fetuses with IUGR. The changes of maternal nutrition, damage of the placenta, and the direct effect of DFMO on the fetus were examined in this IUGR model. Administration of DFMO did not induced changes of maternal nutrition except for triglyceride and the fetal metabolic state. But the placental weight, ODC activity, and DNA in the placenta were decreased significantly. The ODC activity in the total placenta decreased to less than 10 % of that of the control. Depression of ODC activity in the placenta may be the major cause of IUGR induced by DFMO administration, and polyamines play important roles to carry pregnancy. (C) 2002 Elsevier Science Inc. All rights reserved.

引用

页码：1395 / 1405

页数：11