Infusion of cannabidiol into infralimbic cortex facilitates fear extinction via CB1 receptors

被引：72
作者：
Do Monte, Fabricio H. [1 ]
Souza, Rimenez R. [1 ]
Bitencourt, Rafael M. [1 ]
Kroon, Juliana A. [1 ]
Takahashi, Reinaldo N. [1 ]
机构：
[1] Univ Fed Santa Catarina, Ctr Ciencias Biol, Dept Farmacol, Florianopolis, SC, Brazil
来源：
BEHAVIOURAL BRAIN RESEARCH | 2013年 / 250卷
关键词：
Fear extinction; Cannabidiol; CB1; receptor; Infra limbic cortex; Rimonabant; Conditioned freezing; MEDIAL PREFRONTAL CORTEX; CONDITIONED FEAR; CANNABINOID RECEPTOR; MEMORY RECONSOLIDATION; BASOLATERAL AMYGDALA; NEURONS; EXPRESSION; SYSTEM; MODULATION; ANANDAMIDE;
D O I：
10.1016/j.bbr.2013.04.045
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
Previous studies have implicated cannabinoids in extinction of conditioned fear. We have recently showed that intraventricular infusion of the phytocannabinoid cannabidiol (CBD) facilitates fear extinction, but the brain regions underlying this effect remained unknown. Here we demonstrate that repeated microinjections of CBD into the infralimbic cortex (IL) facilitated fear extinction, as indicated by reduced levels of freezing during extinction test. Systemic administration of the CB1 receptor antagonist rimonabant blocked the effects of intra-IL CBD, suggesting that CBD acts through CBI receptors to facilitate fear extinction. Our findings suggest a potential therapeutic use of CBD for extinction-based therapies of aversive memories in humans. (c) 2013 Elsevier B.V. All rights reserved.
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页码：23 / 27
页数：5
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