Genes that Mediate Metastasis across the Blood-Brain Barrier

被引：29

作者：

Fares, Jawad ^{[1
]}

Kanojia, Deepak ^{[1
]}

Rashidi, Aida ^{[1
]}

Ulasov, Ilya ^{[2
]}

Lesniak, Maciej S. ^{[1
]}

机构：

[1] Northwestern Univ, Feinberg Sch Med, Dept Neurol Surg, Chicago, IL 60611 USA

[2] Sechenov First Moscow State Med Univ, Inst Regenerat Med, Grp Expt Biotherapy & Diagnost, Moscow 119991, Russia

来源：

TRENDS IN CANCER | 2020年 / 6卷 / 08期

基金：

美国国家卫生研究院;

关键词：

PLACENTA GROWTH-FACTOR; BREAST-CANCER CELLS; MEMBRANE-BOUND PROTEASE; ENDOTHELIAL-CELLS; DOWN-REGULATION; MELANOMA; EXPRESSION; PERMEABILITY; MIGRATION; TRANSPORT;

D O I：

10.1016/j.trecan.2020.04.007

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Brain metastasis is an important cause of mortality in patients with cancer and represents the majority of all intracranial tumors. A key step during the metastatic journey of the cancer cell to the brain is the invasion through the blood-brain barrier (BBB). Nevertheless, the molecular mechanisms that govern this process remain unknown. The BBB has been blamed for limiting the access of therapeutic drugs to the brain, which provides a safe haven for cancer cells in the brain and confers poor prognosis for the patient. Here, we explore the genes that control the transmigration of metastatic cancer cells across the BBB, offering new targets for the development of gene and cell therapies against brain metastases.

引用

页码：660 / 676

页数：17

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