The role of Hippo/yes-associated protein signalling in vascular remodelling associated with cardiovascular disease

被引：113

作者：

He, Jinlong ^{[1
,2
,3
,4
]}

Bao, Qiankun ^{[1
,2
,3
]}

Yan, Meng ^{[1
,2
,3
]}

Liang, Jing ^{[1
,2
,3
]}

Zhu, Yi ^{[1
,2
,3
]}

Wang, Chunjiong ^{[1
,2
,3
]}

Ai, Ding ^{[1
,2
,3
,4
]}

机构：

[1] Tianjin Med Univ, Dept Physiol & Pathophysiol, Tianjin 300070, Peoples R China

[2] Tianjin Med Univ, Tianjin Key Lab Metab Dis, Tianjin 300070, Peoples R China

[3] Tianjin Med Univ, Collaborat Innovat Ctr Tianjin Med Epigenet, Tianjin 300070, Peoples R China

[4] Tianjin Med Univ, Key Lab Immune Microenvironm & Dis, Minist Educ, Tianjin 300070, Peoples R China

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 2018年 / 175卷 / 08期

基金：

中国国家自然科学基金;

关键词：

ABDOMINAL AORTIC-ANEURYSM; MUSCLE-CELL PROLIFERATION; ORGAN SIZE CONTROL; SMOOTH-MUSCLE; CONCISE GUIDE; EXTRACELLULAR-MATRIX; MESENCHYMAL TRANSITION; ACTIN-BINDING; YAP; PATHWAY;

D O I：

10.1111/bph.13806

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Vascular remodelling is a vital process of a wide range of cardiovascular diseases and represents the altered structure and arrangement of blood vessels. The Hippo pathway controls organ size by regulating cell survival, proliferation and apoptosis. Yes-associated protein (YAP), a transcription coactivator, is a downstream effector of the Hippo pathway. There is growing evidence for the importance of the Hippo/YAP pathway in vascular-remodelling and related cardiovascular diseases. The Hippo/YAP pathway alters extracellular matrix production or degradation and the growth, death and migration of vascular smooth muscle cells and endothelial cells, which contributes to vascular remodelling in cardiovascular diseases such as pulmonary hypertension, atherosclerosis, restenosis, aortic aneurysms and angiogenesis. In this review, we summarize and discuss recent findings about the roles and mechanisms of Hippo/YAP signalling in vascular remodelling and related conditions. Linked ArticlesThis article is part of a themed section on Spotlight on Small Molecules in Cardiovascular Diseases. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v175.8/issuetoc

引用

页码：1354 / 1361

页数：8

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